Mechanical and biological properties of hydroxyapatite/tricalcium phosphate scaffolds coated with poly(lactic-co-glycolic acid)

Miao, Xigeng, Tan, Dawn Meifang, Li, Jian, Xiao, Yin, & Crawford, Ross W. (2008) Mechanical and biological properties of hydroxyapatite/tricalcium phosphate scaffolds coated with poly(lactic-co-glycolic acid). Acta Biomaterialia, 4(3), pp. 638-645.


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Regeneration of bone, cartilage, and osteochondral tissues by tissue engineering has attracted intense attention due to its potential advantages over the traditional replacement of tissues with synthetic implants. Nevertheless, there is still a dearth of ideal or suitable scaffolds based on porous biomaterials and the present study was to develop and evaluate a useful porous composite scaffold system. Here, hydroxyapatite (HA)/ tricalcium phosphate (TCP) scaffolds (average pore size: 500 um; porosity: 87%) were prepared by a polyurethane (PU) foam replica method, followed by modification with infiltration and coating of poly(lactic-co-glycolic acid) (PLGA). The thermal shock resistance of the composite scaffolds was evaluated by measuring the compressive strength before and after quenching or freezing treatment. The porous structure (in terms of pore size, porosity and pore interconnectivity) of the composite scaffolds were examined. The penetration of the bone marrow stromal stem cells (BMSCs) into the scaffolds and the attachment of the cells onto the scaffolds were also investigated. It was shown that the PLGA incorporation in the HA/TCP scaffolds significantly increased the compressive strength up to 660 kPa and the residual compressive strength after the freezing treatment decreased to 160 kPa, which was however sufficient enough for the scaffolds to withstand subsequent cell culture procedures and a freezing drying process. On the other hand, the PLGA coating on the strut surfaces of the scaffolds was rather thin (< 5 um) and apparently porous, maintaining the high open porosity of the HA/TCP scaffolds, resulting in desirable migration and attachment of the bone marrow stromal stem cells, although a thicker PLGA coating would have imparted a higher compressive strength of the PLGA-coated porous HA/TCP composite scaffolds.

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92 citations in Web of Science®
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ID Code: 10286
Item Type: Journal Article
Refereed: Yes
Keywords: Hydroxyapatite, Poly(lactic, co, glycolic acid), Porosity, Quenching, Cell attachment
DOI: 10.1016/j.actbio.2007.10.006
ISSN: 1742-7061
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 Elsevier
Copyright Statement: Reproduced in accordance with the copyright policy of the publisher.
Deposited On: 24 Oct 2007 00:00
Last Modified: 29 Feb 2012 13:32

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