Differential effects on the hepatitis C virus (HCV) internal ribosome entry site by vitamin B12 and the HCV core protein

Dongsheng, Li, Lott, William, Martyn, John, Haqshenas, Gholamreza, & Gowans, Eric J. (2004) Differential effects on the hepatitis C virus (HCV) internal ribosome entry site by vitamin B12 and the HCV core protein. Journal of Virology, 78(21), pp. 12075-12081.

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Abstract

To investigate the role of the hepatitis C virus internal ribosome entry site (HCV IRES) domain IV in translation initiation and regulation, two chimeric IRES elements were constructed to contain the reciprocal domain IV in the otherwise HCV and classical swine fever virus IRES elements. This permitted an examination of the role of domain IV in the control of HCV translation. A specific inhibitor of the HCV IRES, vitamin B12, was shown to inhibit translation directed by all IRES elements which contained domain IV from the HCV and the GB virus B IRES elements, whereas the HCV core protein could only suppress translation from the wild-type HCV IRES. Thus, the mechanisms of translation inhibition by vitamin B12 and the core protein differ, and they target different regions of the IRES.

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11 citations in Web of Science®

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ID Code: 10445
Item Type: Journal Article
Refereed: Yes
DOI: 10.1128/JVI.78.21.12075-12081.2004
ISSN: 0022-538X
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2004 American Society for Microbiology
Deposited On: 26 Oct 2007 00:00
Last Modified: 29 Feb 2012 13:19

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