Microcarriers in the Engineering of Cartilage and Bone

Malda, Johannes & Frondoza, Carmelita G. (2006) Microcarriers in the Engineering of Cartilage and Bone. Trends in Biotechnology, 24(7), pp. 299-304.

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A major problem in tissue engineering is the availability of a sufficient number of cells with the appropriate phenotype for delivery to damaged or diseased cartilage and bone; the challenge is to amplify cell numbers and maintain the appropriate phenotype for tissue repair and restoration of function. The microcarrier bioreactor culture system offers an attractive method for cell amplification and enhancement of phenotype expression. Besides serving as substrates for the propagation of anchorage-dependent cells, microcarriers can also be used to deliver the expanded undifferentiated or differentiated cells to the site of the defect. The present article provides an overview of the microcarrier culture system, its utility as an in vitro research tool and its potential applications in tissue engineering, particularly in the repair of cartilage and bone.

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109 citations in Scopus
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102 citations in Web of Science®

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ID Code: 10498
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal's website (see hypertext link) or contact the author.
DOI: 10.1016/j.tibtech.2006.04.009
ISSN: 0167-7799
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2006 Elsevier
Deposited On: 30 Oct 2007 00:00
Last Modified: 22 Feb 2013 06:11

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