QUT ePrints

Biomechanical responses of normal and delipidized articular cartilage subjected to varying rates of loading

Oloyede, Adekunle, Gudimetla, Prasad V., Crawford, Ross W., & Hills, Brian (2004) Biomechanical responses of normal and delipidized articular cartilage subjected to varying rates of loading. Connective Tissue Research, 45(2), pp. 86-93.

View at publisher

Abstract

In alignment with the proposition that a lipid layer overlays the superficial zone of the articular cartilage, this study presents the consequence of the removal of lipids on the load-bearing characteristics of the tissue. Both normal unmodified and delipidized cartilage matrices were loaded at four different strain-rates of 1.3×10 -4 /s, 1.3×10 -3 /s, 1.3×10 -2 /s, and 1.3×10 -1 /s to strains of no more than 40%, to compare their stress-strain and stiffness-strain-rate characteristics. Our results demonstrate that at the lowest strain-rate of 1.3×10 -4 /s, the stiffness of the delipidized matrix was lower in comparison to that of the normal unmodified tissue. This response was reversed at higher strain-rates of 1.3×10 -2 /s and above. We conclude, therefore, that in general, at physiological rates of loading, the depletion of lipids from the articular cartilage reduces its compliance by at least 25%. We infer from the present study that this degenerative stiffening is an important contributing factor in impairing the tissue's load processing function in osteoarthritic joints.

Impact and interest:

11 citations in Scopus
Search Google Scholar™
8 citations in Web of Science®

Citation countsare sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 10502
Item Type: Journal Article
DOI: 10.1080/03008200490442653
ISSN: 0300-8207
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2004 Taylor and Francis
Copyright Statement: First published in Connective Tissue Research, Volume 45, Number 2, March-April 2004 , pp. 86-93(8)
Deposited On: 30 Oct 2007
Last Modified: 29 Feb 2012 23:06

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page