Biomechanical responses of normal and delipidized articular cartilage subjected to varying rates of loading

Oloyede, Adekunle, Gudimetla, Prasad V., Crawford, Ross W., & Hills, Brian (2004) Biomechanical responses of normal and delipidized articular cartilage subjected to varying rates of loading. Connective Tissue Research, 45(2), pp. 86-93.

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In alignment with the proposition that a lipid layer overlays the superficial zone of the articular cartilage, this study presents the consequence of the removal of lipids on the load-bearing characteristics of the tissue. Both normal unmodified and delipidized cartilage matrices were loaded at four different strain-rates of 1.3×10 -4 /s, 1.3×10 -3 /s, 1.3×10 -2 /s, and 1.3×10 -1 /s to strains of no more than 40%, to compare their stress-strain and stiffness-strain-rate characteristics. Our results demonstrate that at the lowest strain-rate of 1.3×10 -4 /s, the stiffness of the delipidized matrix was lower in comparison to that of the normal unmodified tissue. This response was reversed at higher strain-rates of 1.3×10 -2 /s and above. We conclude, therefore, that in general, at physiological rates of loading, the depletion of lipids from the articular cartilage reduces its compliance by at least 25%. We infer from the present study that this degenerative stiffening is an important contributing factor in impairing the tissue's load processing function in osteoarthritic joints.

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ID Code: 10502
Item Type: Journal Article
Refereed: Yes
DOI: 10.1080/03008200490442653
ISSN: 0300-8207
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2004 Taylor and Francis
Copyright Statement: First published in Connective Tissue Research, Volume 45, Number 2, March-April 2004 , pp. 86-93(8)
Deposited On: 30 Oct 2007 00:00
Last Modified: 29 Feb 2012 13:06

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