Interaction of Microbiology and Pathology in Women Undergoing Investigations for Infertility

Debattista, Joseph, Gazzard, Caroline M., Wood, Robyn N., Allan, John A., Allan, Janet M., Scarman, Anthony, Mortlock, Miranda, Timms, Peter, & Knox, Christine L. (2005) Interaction of Microbiology and Pathology in Women Undergoing Investigations for Infertility. Infectious Diseases in Obstetrics and Gynecology, 12(3-4), pp. 135-145.

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Background: Cases of endometriosis with no tubal damage are associated with infertility, suggesting an immunological rather than mechanical barrier to reproduction. Laparoscopy and falloposcopy results of clinically asymptomatic women undergoing investigation of infertility were correlated with the outcomes of microbiological screening for Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, ureaplasma species, Neisseria gonorrhoeae, Neisseria meningitidis and Chlamydia pneumoniae.

Methods: A total of 44 women presenting to a hospital IVF service for laparoscopic or laparoscopic/ falloposcopic investigation of infertility provided endocervical swabs, fallopian tube washings, and peripheral whole blood for analysis.

Results: Of these 44 women, 15.9% (7) showed evidence of C. trachomatis infection as detected by either PCR or EIA serology. Of these 7 women, 5 (71%) had no or mild endometriosis and 2 (29%) had moderate or severe endometriosis. Of the remaining 37 women who showed no evidence of chlamydial infection, 15 (40.5%) had no or mild endometriosis.

Conclusion: Women with infertility, but without severe endometriosis at laparoscopy, showed a trend towards tubal damage and a higher rate of previous C. trachomatis infection. Although not statistically significant, this trend would suggest that, where moderate to severe tubal damage is found to be the primary cause of infertility, C. trachomatis infection could be a likely cause for such tubal damage.

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ID Code: 10691
Item Type: Journal Article
Refereed: Yes
Additional Information: The contents of this journal can be freely accessed online via the journal’s web page (see hypertext link).
DOI: 10.1080/10647440400020703
ISSN: 1064-7449
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2005 (The authors)
Deposited On: 13 Nov 2007 00:00
Last Modified: 29 Feb 2012 13:11

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