Is contact lens induced corneal oedema inflammatory?

Efron, Nathan (1985) Is contact lens induced corneal oedema inflammatory? Australian Journal of Optometry, 68(5), pp. 167-172.


The development of corneal oedema during hydrogel contact lens wear is well documented; however, the magnitude of lens-induced swelling cannot be completely explained in terms of a response to hypoxia. This paper examines whether there may, in addition to other factors, be an inflammatory component in the aetiology of contact lens induced corneal oedema. A hypothesis is advanced – that hypoxia induced by a contact lens stimulates the release of prostaglandins from the cornea, which interfere with endothelial control of corneal hydration, resulting in corneal oedema. This hypothesis was tested by studying the effects of the prostaglandin-inhibitor naproxen on contact lens induced corneal oedema. Naproxen was found to have no measurable effect. The clinical and physiological implications of this result are discussed.

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ID Code: 10811
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Hydrogel contact lens, cornea, corneal oedema, prostaglandins, prostaglandin, inhibitor, inflammation, naproxen
ISSN: 0045-0642
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Past > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1985 Optometrists Association Australia
Deposited On: 19 Nov 2007 00:00
Last Modified: 09 Jun 2010 12:49

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