Is contact lens induced corneal oedema inflammatory?
Efron, Nathan (1985) Is contact lens induced corneal oedema inflammatory? Australian Journal of Optometry, 68(5), pp. 167-172.
The development of corneal oedema during hydrogel contact lens wear is well documented; however, the magnitude of lens-induced swelling cannot be completely explained in terms of a response to hypoxia. This paper examines whether there may, in addition to other factors, be an inflammatory component in the aetiology of contact lens induced corneal oedema. A hypothesis is advanced – that hypoxia induced by a contact lens stimulates the release of prostaglandins from the cornea, which interfere with endothelial control of corneal hydration, resulting in corneal oedema. This hypothesis was tested by studying the effects of the prostaglandin-inhibitor naproxen on contact lens induced corneal oedema. Naproxen was found to have no measurable effect. The clinical and physiological implications of this result are discussed.
Impact and interest:
Citation countsare sourced monthly fromand citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
Full-text downloadsdisplays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.
|Item Type:||Journal Article|
|Keywords:||Hydrogel contact lens, cornea, corneal oedema, prostaglandins, prostaglandin, inhibitor, inflammation, naproxen|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)|
|Divisions:||Current > Research Centres > Centre for Health Research|
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 1985 Optometrists Association Australia|
|Deposited On:||19 Nov 2007|
|Last Modified:||09 Jun 2010 22:49|
Repository Staff Only: item control page