Oxygen uptake profile of the human cornea
A polarographic oxygen sensor was used to measure corneal oxygen uptake (COU) centrally and 4mm proximally at nasal, temporal, superior, and inferior locations on 10 human subjects. The mean COU rates (±SEM) were 6.23 ± 0.25, 6.27 ± 0.40, 6.26 ± 0.35, 5.99 ± 0.29 and 6.26 ± 0.37 ml/cm2/h, respectively. There was no statistically significant difference between any of these measurements, thus confirming earlier predictions based on a rabbit eye model. The importance of retracting the eyelids for a prolonged period (5 min) prior to obtaining measurements of COU at the superior corneal site is demonstrated. This data provides a topographical baseline reference of COU, and has implications with respect to the monitoring of corneal disease and the design of contact lenses.
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|Item Type:||Journal Article|
|Keywords:||Polarographic oxygen sensor, corneal oxygen uptake, topographic measurements, human|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)|
|Divisions:||Current > Research Centres > Centre for Health Research|
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 1986 Optometrists Association Australia|
|Deposited On:||19 Nov 2007|
|Last Modified:||09 Jun 2010 22:49|
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