Strategies for minimising the ocular effects of extended contact lens wear - a statistical analysis

Holden, Brien A., Swarbrick, Helen A., Sweeney, Deborah F., Ho, Arthur, Efron, Nathan, Vannas, Antti, & Nilsson, Klas T. (1987) Strategies for minimising the ocular effects of extended contact lens wear - a statistical analysis. American Journal of Optometry and Physiological Optics, 64(10), pp. 781-789.


In a study reported recently, the effects of long-term extended wear of soft contact lenses on the human cornea were found to include epithelial thinning, a reduction in epithelial oxygen uptake, induction of epithelial microcysts, stromal thinning, and an increase in endothelial polymegathism. A multiple regression analysis was performed on data from this study to identify lens or patient characteristics associated with these effects. Although generalization to the population of conclusions based on associations identified using a small sample should be treated with caution, results from this analysis suggest that lens-induced effects on the cornea may be minimized by fitting lenses that are thinner and more mobile, and by encouraging more frequent lens removal and replacement. Patients with thinner corneas and with high endothelial cell density and low polymegathism before commencing lens wear tended to show fewer effects from extended lens wear.

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4 citations in Web of Science®

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ID Code: 10924
Item Type: Journal Article
Refereed: Yes
Additional Information: Self-archiving of the author-version is not yet supported by this publisher.
For more information, please refer to the journal's website (see hypertext link) or contact the author.
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Keywords: Contact lenses, extended wear, contact lens, induced effects, statistical analysis, multiple regression analysis
ISSN: 0093-7002
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1987 American Academy of Optometry
Deposited On: 27 Nov 2007 00:00
Last Modified: 10 Aug 2011 17:43

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