Pathogenesis of contact lens induced bacterial corneal ulcers - a review and an hypothesis
Fleiszig, Suzanne & Efron, Nathan (1988) Pathogenesis of contact lens induced bacterial corneal ulcers - a review and an hypothesis. Clinical and Experimental Optometry, 71(5), pp. 147-157.
Previous research into the aetiology of contact lens-related infection has focussed upon a) the ability of bacteria such as P. aeruginosa to adhere to contact lenses, b) the role of lens contamination, and c) patient compliance factors. However, these studies have not fully explained the increased susceptibility to P. aeruginosa infection during lens wear. It is argued that bacterial adherence to the corneal epithelium is a prerequisite for the development of corneal infection. We explore the possibility of an aetiological role in contact lens related infection for fibronectin, a glycoprotein that is associated with some cell surfaces and body fluids, by drawing upon published mechanisms of bacterial adherence to human buccal mucosa in cystic fibrosis. An hypothesis is presented that contact lenses deplete fibronectin in the tears and/or corneal epithelium, allowing bacteria to adhere to the epithelium, resulting in corneal infection.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.
|Item Type:||Journal Article|
|Additional Information:||The contents of this journal from 1998 to 2005 can be freely accessed online via the journal's web page (see link).|
|Keywords:||Cornea, contact lens, corneal infection, bacterial adherence, Pseudomonas aeruginosa, fibronectin, sialic acid, cystic fibrosis|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)|
|Divisions:||Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 1988 Optometrists Association Australia|
|Deposited On:||27 Nov 2007 00:00|
|Last Modified:||10 Aug 2011 14:07|
Repository Staff Only: item control page