Pathogenesis of contact lens induced bacterial corneal ulcers - a review and an hypothesis

Fleiszig, Suzanne & Efron, Nathan (1988) Pathogenesis of contact lens induced bacterial corneal ulcers - a review and an hypothesis. Clinical and Experimental Optometry, 71(5), pp. 147-157.



Previous research into the aetiology of contact lens-related infection has focussed upon a) the ability of bacteria such as P. aeruginosa to adhere to contact lenses, b) the role of lens contamination, and c) patient compliance factors. However, these studies have not fully explained the increased susceptibility to P. aeruginosa infection during lens wear. It is argued that bacterial adherence to the corneal epithelium is a prerequisite for the development of corneal infection. We explore the possibility of an aetiological role in contact lens related infection for fibronectin, a glycoprotein that is associated with some cell surfaces and body fluids, by drawing upon published mechanisms of bacterial adherence to human buccal mucosa in cystic fibrosis. An hypothesis is presented that contact lenses deplete fibronectin in the tears and/or corneal epithelium, allowing bacteria to adhere to the epithelium, resulting in corneal infection.

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7 citations in Scopus
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ID Code: 10931
Item Type: Journal Article
Refereed: Yes
Additional Information: The contents of this journal from 1998 to 2005 can be freely accessed online via the journal's web page (see link).
Additional URLs:
Keywords: Cornea, contact lens, corneal infection, bacterial adherence, Pseudomonas aeruginosa, fibronectin, sialic acid, cystic fibrosis
ISSN: 0816-4622
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Past > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1988 Optometrists Association Australia
Deposited On: 27 Nov 2007 00:00
Last Modified: 10 Aug 2011 14:07

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