Morphology of corneal nerves in soft contact lens wear. A comparative study using confocal microscopy

Oliveira-Soto, Laura & Efron, Nathan (2003) Morphology of corneal nerves in soft contact lens wear. A comparative study using confocal microscopy. Ophthalmic and Physiological Optics, 23(2), pp. 163-174.

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The aim of this study was to evaluate corneal innervation in soft contact lens wearers using the Tomey Confoscan confocal microscope (40x/0.75 objective lens). Three distinct age- and sex-matched subject groups were involved, including extended soft (hydrogel and silicone-hydrogel) contact lens wearers, overnight soft (hydrogel) contact lens wearers, and non contact lens wearers. A number of variables were objectively measured, subjectively evaluated, or graded in order to investigate the distribution and morphology of corneal nerves. For most of the evaluated parameters, no statistically significant differences were found. However, qualitative observations showed noticeable differences in corneal nerve appearance among the different subject groups; the degree of corneal oedema was suggested as the main causative factor. In conclusion, neither the short-term (overnight wear) nor the long-term (12-month extended wear) soft contact lens wear appeared to affect the morphology and/or distribution of corneal nerves as viewed with confocal microscopy.

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35 citations in Scopus
28 citations in Web of Science®
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ID Code: 11019
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal's website (see hypertext link) or contact the author.
Keywords: confocal microscopy, corneal oedema, corneal nerves, extended contact lens we
DOI: 10.1046/j.1475-1313.2003.00106.x
ISSN: 0275-5408
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2003 Blackwell Publishing
Deposited On: 28 Nov 2007 00:00
Last Modified: 29 Feb 2012 13:29

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