Confocal microscopic evaluation of particles at the corneal flap interface after myopic laser in situ keratomileusis
Perez-Gomez, Inma & Efron, Nathan (2003) Confocal microscopic evaluation of particles at the corneal flap interface after myopic laser in situ keratomileusis. Journal Of Cataract And Refractive Surgery, 29(7), pp. 1373-1377.
PURPOSE: To investigate the appearance and origin of interface particles in the cornea after myopic laser in situ keratomileusis (LASIK) using the confocal microscope. SETTING: Department of Optometry and Neuroscience, UMIST, Manchester, United Kingdom. METHODS: An in vivo slit-scanning, real-time confocal microscope (Tomey ConfoScan P4) fitted with an Achroplan(R) 40X/0.75 NA immersion objective (Zeiss) was used to examine the morphology of the central cornea in 6 patients (12 eyes) at the initial visit (before surgery) and 1 week and 1, 3, and 6 months after LASIK for myopia. RESULTS: In all eyes, several interspersed particles of variable size and brightness were observed 1 week after surgery at the flap interface. The overall density of these particles decreased with time (F = 14.34, P =.01). For analysis, the particles were divided by density into high brightness and low brightness. The low-brightness particles significantly decreased with time (F = 13.26, P =.02). The high-brightness particles remained constant in density at all postoperative visits (F = 1.3, P =.15). CONCLUSIOINS: The particles of low reflectivity may represent 1 or more types of remains. It is unclear whether the low-reflectivity particles will eventually disappear. The high-reflectivity particles may represent fine metallic debris arising from the mechanical drive mechanism and/or the disposable knife of the microkeratome. If they are metallic and magnetic, they could be cleared during surgery (immediately before flap replacement) using a specially adapted magnet.
Impact and interest:
Citation countsare sourced monthly fromand citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Additional Information:||For more information, please refer to the journal's website (see hypertext link) or contact the author.|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)|
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
|Divisions:||Current > Research Centres > Centre for Health Research|
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2003 Elsevier|
|Deposited On:||28 Nov 2007|
|Last Modified:||29 Feb 2012 23:29|
Repository Staff Only: item control page