Confocal microscopy of the corneas of long-term rigid contact lens wearers

Hollingsworth, Joanna G. & Efron, Nathan (2004) Confocal microscopy of the corneas of long-term rigid contact lens wearers. Contact Lens and Anterior Eye, 27(2), pp. 57-64.

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Slit scanning confocal microscopy (Tomey Confoscan P4) was used to evaluate the central cornea of 22 subjects who had been wearing rigid lenses on a long-term, daily wear basis. Anterior and posterior keratocyte densities appeared unaffected by rigid lens wear (P = 0.10 and 0.34 for anterior and posterior keratocyte densities, respectively). Subjects with a previous history of polymethyl methacrylate (PMMA) lens wear showed a reduction in anterior keratocyte density (AKD) (P < 0.0001) and an increased level of haze in the anterior stroma. This may represent previous hypoxic damage. Endothelial cell density (ECD) was unaffected by rigid lens wear (P = 0.36) although an increase in endothelial polymegethism was evident (P < 0.0001). Subjects who had only worn rigid lenses with no history of PMMA lens wear did not show an increase in endothelial polymegethism (P = 0.10). An increased number of microdot opacities compared to the non-lens wearing eye was apparent (P = 0.05). The number of microdot opacities induced by rigid lenses, as reported in this study, appears to be less than that reported by others in respect of soft lenses.

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ID Code: 11043
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author.
Keywords: Confocal microscopy, Cornea, Rigid contact lens
DOI: 10.1016/j.clae.2004.02.002
ISSN: 1367-0484
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Elsevier
Deposited On: 28 Nov 2007 00:00
Last Modified: 29 Feb 2012 13:29

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