Short-term physiologic response in neophyte subjects fitted with hydrogel and silicone hydrogel contact lenses

Maldonado-Codina, Carole, Morgan, Philip B., Schnider, Cristina M., & Efron, Nathan (2004) Short-term physiologic response in neophyte subjects fitted with hydrogel and silicone hydrogel contact lenses. Optometry and Vision Science, 81(12), pp. 911-921.


PURPOSE: To investigate the short-term physiologic response to three soft lens materials with different oxygen permeability characteristics. METHODS: Forty-three neophytes were randomly prescribed Acuvue 2, Acuvue Advance (Johnson & Johnson Vision Care), or Focus Night & Day (CIBA Vision) for 4 weeks on a daily-wear basis. A further 19 subjects did not wear lenses (control). Experimental and control subjects were examined 2 and 4 weeks after dispensing. Ocular physiologic response was measured with a slitlamp biomicroscope in a strictly masked fashion. RESULTS: Limbal redness increased in the Acuvue 2 group compared with the other two groups. Conjunctival redness increased more in the Acuvue 2 group than in the Acuvue Advance group. More conjunctival staining was seen with the Acuvue Advance and Focus Night & Day groups compared with the Acuvue 2 group. Increased scores for papillary conjunctivitis were seen in the Focus Night & Day group compared with the Acuvue Advance group. CONCLUSIONS: The reduced level of limbal redness seen with the Acuvue Advance and Focus Night & Day groups suggests that these lenses provide more oxygen to the ocular surface than the Acuvue 2 lens to a degree that can be observed clinically. The conjunctival staining response was similar for the Acuvue Advance and Focus Night & Day groups. The results for the Acuvue Advance and Focus Night & Day groups for papillary conjunctivitis may reflect differences in their material and surface properties.

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ID Code: 11054
Item Type: Journal Article
Refereed: Yes
Additional Information: The contents of this journal can be freely accessed online via the journal's web page (see hypertext link) 12 months after publication. Self-archiving of the author-version is not yet supported by this publisher.
For more information, please refer to the journal’s website or contact the author.
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Keywords: conjunctival redness, limbal redness, oxygen transmissibility, papillary conjunctivitis, soft contact lens, silicone hydrogel
ISSN: 1538-9235
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Lippincott Williams & Wilkins
Deposited On: 29 Nov 2007 00:00
Last Modified: 29 Feb 2012 13:29

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