The size, location, and clinical severity of corneal infiltrative events associated with contact lens wear
Efron, Nathan, Morgan, Philip B., Hill, Elizabeth A., Raynor, Mathew K., & Tullo, Andrew B. (2005) The size, location, and clinical severity of corneal infiltrative events associated with contact lens wear. Optometry And Vision Science, 82(6), pp. 519-527.
PURPOSE: The purpose of this study is to determine the relationship between the size, location, and clinical severity of corneal infiltrative events (CIEs) associated with contact lens wear. METHODS: We examined a series of contact lens wearers, presenting consecutively to a large hospital clinic, who had any form of CIE. The severity of the CIE was quantified using a clinical severity matrix based on scores attributed to each of 10 signs and symptoms. The infiltrate was accurately drawn on a schematic diagram of the ocular surface, and from this, we determined its size (i.e., largest dimension) and distance from the limbus. Cartograms were constructed to illustrate the size and location of the corneal infiltrates according to wearing modality and lens type. RESULTS: Useable data pertaining to 111 patients were analyzed. A significant positive correlation was found between the distance of the infiltrate from the limbus versus clinical severity (p = 0.002), but not between the distance of the infiltrate from the limbus versus infiltrate size (p = 0.97). The cartograms revealed a tendency for infiltrates to occur in the superior cornea of patients wearing extended wear silicone hydrogel lenses (p = 0.0002) in the central cornea of patients wearing daily wear hydrogel daily disposable lenses (p = 0.007) and in the peripheral cornea of patients wearing daily wear hydrogel (excluding daily disposable) lenses (p = 0.0006). CONCLUSIONS: These data statistically validate the previously held anecdotal notion that CIEs which occur in the peripheral cornea are less clinically severe than those which occur in the central cornea. Consideration of the distribution of CIEs may facilitate a better understanding of the etiology of these events and can serve to alert practitioners as to their likely clinical presentation.
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|Item Type:||Journal Article|
|Additional Information:||The contents of this journal can be freely accessed online via the journal's web page (see hypertext link) 12 months after publication. For more information, please refer to the journal's website (see hypertext link) or contact the author.|
|Keywords:||corneal infiltrative events, contact lens, clinical severity, distribution, location, infiltrate size, distance from limbus|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)|
|Divisions:||Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2005 Lippincott Williams & Wilkins|
|Deposited On:||29 Nov 2007 00:00|
|Last Modified:||29 Feb 2012 13:29|
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