Meta-analysis of the use of antiseptics for pre-operative showering to prevent surgical site infection
Background: Preoperative bathing or showering with an antiseptic solution is used to prevent surgical site wound infection. Conflicting trial results suggest a critical review is necessary. Methods: We systematically reviewed randomized controlled trials. Studies were identified by computer searches of Medline, Embase and the Cochrane controlled trials register. Trials were eligible if they compared pre-operative bathing or showering using an antiseptic solution with a non-antiseptic wash agent or with no shower, and if they reported data on surgical site infection. Results: Six trials involving a total of 10,007 participants were included. 4% chlorhexidine gluconate (Hibiscrub) was used in all trials. Three trials involving 7691 participants compared Hibiscrub with a placebo. Bathing with chlorhexidine did not reduce surgical site wound infection rate; the relative risk (RR) was 0.91 (95% confidence interval (CI) 0.80 to 1.04). When only trials of high quality were included in this comparison, the RR was 0.95 (95% CI 0.82 to 1.10). Three trials of 1443 participants compared bar soap with chlorhexidine; no differences in the surgical site infection rates were detected, the RR was 1.02 (95% CI 0.57 to 1.84). Two trials of 1092 patients compared bathing with chlorhexidine with no washing. The surgical site wound infection rate in the two groups was similar, the RR was 0.70 (95% CI 0.19 to 2.58). Conclusions: Current evidence does not support pre-operative showering or bathing with chlorhexidine to reduce surgical site wound infection rates.
Impact and interest:
Citation countsare sourced monthly fromand citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
Full-text downloadsdisplays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.
|Item Type:||Journal Article|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NURSING (111000)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
Current > Schools > School of Nursing
|Copyright Owner:||Copyright 2006 John Wiley & Sons|
|Copyright Statement:||The definite version is available on publication at www3.interscience.wiley.com|
|Deposited On:||10 Dec 2007|
|Last Modified:||29 Feb 2012 23:26|
Repository Staff Only: item control page