Confocal microscopy observations of the cornea in response to contact lens wear

Efron, Nathan & Mutalib, Haliza A. (2001) Confocal microscopy observations of the cornea in response to contact lens wear. die Kontaktlinse, 35(1), pp. 4-16.


A new clinical instrument which has recently become available – the slit-scanning confocal microscope – allows the living human cornea to be viewed at a magnification of 680X and a lateral resolution of 1µm. Thus, corneal morphology can be inspected at a cellular level with this instrument. The corneas of contact lens wearers were examined using a Tomey ConfoScan P4 in-vivo slit-scanning real-time confocal microscope (Erlangen, Germany). Specific consideration is given to the topics of lens-induced alterations to epithelial cell morphology, corneal oedema, stromal thinning, stromal microdots and endothelial blebs. Representative confocal images are presented and simple models are used to help explain certain phenomena revealed in these images. It is concluded that the technique of confocal microscopy has enormous potential as a research tool and clinical instrument for assessing the ocular response to contact lens wear.

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ID Code: 11500
Item Type: Journal Article
Refereed: No
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author.
Additional URLs:
Keywords: confocal microscope, cornea, contact lens
ISSN: 0721-5096
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2001 Konradin Publishing Group
Deposited On: 08 Jan 2008 00:00
Last Modified: 10 Aug 2011 16:24

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