Local neuroretinal function during acute hypoxia in healthy older people

Feigl, Beatrix, Stewart, Ian B., Brown, Brian, & Zele, Andrew J. (2008) Local neuroretinal function during acute hypoxia in healthy older people. Investigative Ophthalmology and Visual Science, 49(2), pp. 807-813.

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Abstract

Purpose To measure the effect of acute, mild, systemic hypoxia on neuroretinal function in two different age groups.

Methods The slow-flash paradigm of the multifocal electroretinogram (mfERG) was measured in two different oxygenation levels. Twelve participants of two age groups (28 ± 4 and 55 ± 5 years) breathed room air (normoxia) or 12% oxygen (hypoxia).

Results During normoxia (SaO2 = 98%) there was a significantly different effect between the younger and older participants on the mfERG positive waveform components (N1P1 amplitudes and P1 implicit times; P < 0.001). Hypoxia (SaO2 = 90%) significantly decreased N1P1 response density amplitudes in the central retinal field in both groups, with a larger effect in the older group (P < 0.001). There was no significant change in function of the cellular generators of oscillatory potentials (OPs).

Conclusion The results extend recent findings by showing a greater effect of hypoxia on ON- and OFF-bipolar cell function in healthy older persons than in younger persons, but no effect on OPs during moderate acute hypoxia in either age group.

Impact and interest:

13 citations in Scopus
13 citations in Web of Science®
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ID Code: 12159
Item Type: Journal Article
Refereed: Yes
DOI: 10.1167/iovs.07-0994
ISSN: 1552-5783
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Optical Technology (111302)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 Association for Research in Vision and Ophthalmology
Deposited On: 23 Jan 2008 00:00
Last Modified: 09 Dec 2016 04:22

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