Local neuroretinal function during acute hypoxia in healthy older people
Feigl, Beatrix, Stewart, Ian B., Brown, Brian, & Zele, Andrew J. (2008) Local neuroretinal function during acute hypoxia in healthy older people. Investigative Ophthalmology and Visual Science, 49(2), pp. 807-813.
Purpose: To measure acute mild systemic hypoxia on neuroretinal function in two different age groups. Methods: The slow-flash paradigm of the multifocal electroretinogram (mfERG) was measured in two different oxygenation levels. Twelve participants of two age groups (28±4 and 55±5 years) breathed room air (normoxia) or 12% oxygen (hypoxia). Results: During normoxia (SaO2 = 98%) there was a significant effect between the younger and older participants on the mfERG positive waveform components (N1P1 amplitudes and P1- implicit times) (p < 0.001). Hypoxia (SaO2 = 90%) significantly decreased N1P1 response density amplitudes in the central retinal field in both groups, with a larger effect in the older group (p < 0.001). There was no significant change in function of the cellular generators of oscillatory potentials (OPs). Conclusion: Our results extend recent findings by showing a greater effect of hypoxia effect on ON- and OFF-bipolar cell function in healthy older persons compared to younger persons, but no effect on OPs during moderate acute hypoxia in either age group.
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|Item Type:||Journal Article|
|Additional Information:||For more information, please refer to the journal’s website (see hypertext link) or contact the author.|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)|
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Optical Technology (111302)
|Divisions:||Current > Research Centres > Centre for Health Research|
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2008 Association for Research in Vision and Ophthalmology|
|Deposited On:||23 Jan 2008|
|Last Modified:||13 Nov 2012 08:35|
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