Experimental hypoxia in human eyes: implications for ischaemic disease
OBJECTIVE: This study investigated neuroretinal activity under normoxic and hypoxic conditions with the multifocal electroretinogram (mfERG). METHODS: We used two mfERG paradigms, the fast flicker and slow flash stimulation modes, to measure neuroretinal activity in five healthy participants who breathed room air and a reduced oxygen mixture (14% oxygen, balance nitrogen). We analysed concentric ring N1P1 and P1N2 response density amplitudes, the P1 implicit times as well as the local scalar product (SP) response densities. RESULTS: During hypoxia there was a significant reduction of the scalar product response density for the fast flicker (p<0.001) and for the slow flash mfERG (p<0.001). The N1P1 and P1N2 response densities were lower especially for the central three rings; although these reductions were not significant between the two oxygen conditions, they indicated an overall distortion of the mfERG waveform. CONCLUSIONS: It is demonstrated that a post-receptoral, primarily ON and OFF bipolar cell deficit is evident in the central retina of healthy young people during short term hypoxia. SIGNIFICANCE: Our findings suggest that persons with pre-existing ischaemic eye disease may be at risk when exposed to hypoxic conditions.
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|Item Type:||Journal Article|
|Additional Information:||For more information, please refer to the journal’s website (see hypertext link) or contact the author.|
|Keywords:||Hypoxia, Neuroretinal activity, Multifocal electroretinogram, ON/OFF bipolar cells, Fast adaptation|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)|
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
|Divisions:||Current > Research Centres > Centre for Health Research|
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2007 Elsevier|
|Deposited On:||13 Feb 2008|
|Last Modified:||29 Feb 2012 23:36|
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