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Multifocal ERG in multiple evanescent white dot syndrome

Feigl, Beatrix, Haas, Anton, & El-Shabrawi, Yosuf (2002) Multifocal ERG in multiple evanescent white dot syndrome. Graefe's Archive for Clinical and Experimental Ophthalmology, 240(8), pp. 615-621.

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Abstract

PURPOSE: To investigate the electrophysiological findings of a multifocal ERG in multiple evanescent white dot syndrome (MEWDS). METHODS: Multifocal electroretinograms (mf-ERG) were recorded from four patients with MEWDS. The stimulus array consisted of 61 hexagons and was presented according to a binary m-sequence. We analyzed the N1- and P1-wave amplitudes as well as P1 latencies of the first-order kernels. Local responses and concentric ring averaged responses were compared to 20 age-matched normal subjects. All patients underwent fluorescein angiography and indocyanine green angiography. RESULTS: In two patients, first-order kernel of N1- and P1-wave amplitudes showed supernormal results at the very beginning (day 1 to day 7) of the disease. By 2 weeks later, N1- and P1-wave amplitudes had decreased to either normal or subnormal values. The two patients who presented 2 weeks after the onset of clinical signs showed subnormal or decreased amplitudes. The P1 implicit times were within normal limits in all patients. CONCLUSION: Our mf-ERG findings show different results during the course of the disease. First-order kernel amplitudes seem to reflect early disturbances of the photoreceptors in MEWDS and are therefore useful in detecting early stages and following up the disease.

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9 citations in Web of Science®

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ID Code: 12448
Item Type: Journal Article
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author.
DOI: 10.1007/s00417-002-0478-7
ISSN: 1435-702X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Optical Technology (111302)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2002 Springer
Copyright Statement: The original publication is available at SpringerLink http://www.springerlink.com
Deposited On: 13 Feb 2008
Last Modified: 22 Apr 2010 03:15

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