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Chlamydia trachomatis infection: host immune responses and potential vaccines

Hafner, Louise M., Beagley, Kenneth W., & Timms, Peter (2008) Chlamydia trachomatis infection: host immune responses and potential vaccines. Mucosal Immunology, 1(2), pp. 116-130.

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Abstract

Chlamydia trachomatis causes genital tract infections that affect men, women, and children on a global scale. This review focuses on innate and adaptive immune responses in the female reproductive tract (FRT) to genital tract infections with C. trachomatis. It covers C. trachomatis infections and highlights our current knowledge of genital tract infections, serovar distribution, infectious load, and clinical manifestations of these infections in women. The unique features of the immune system of the FRT will be discussed and will include a review of our current knowledge of innate and adaptive immunity to chlamydial infections at this mucosal site. The use of animal models to study the pathogenesis of, and immunity to, Chlamydia infection of the female genital tract will also be discussed and a review of recent immunization and challenge experiments in the murine model of chlamydial FRT infection will be presented.

Impact and interest:

25 citations in Scopus
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20 citations in Web of Science®

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ID Code: 12508
Item Type: Journal Article
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author.
DOI: 10.1038/mi.2007.19
ISSN: 1935-3456
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Infectious Agents (060502)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 Nature Publishing Group
Deposited On: 18 Feb 2008
Last Modified: 29 Feb 2012 23:42

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