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Changes in lens dimensions and refractive index with age and accommodation

Jones, Catherine E., Atchison, David A., & Pope, James M. (2007) Changes in lens dimensions and refractive index with age and accommodation. Optometry And Vision Science, 84(10), pp. 990-995.

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Abstract

PURPOSE: To measure changes in human eye lens dimensions and refractive index with age and state of accommodation. METHODS: MRI methods were used to measure refractive index maps and lens geometry (diameter and thickness) of an axial slice through the lens in 44 volunteers aged 18 to 59 years, with an accommodation stimulus of 0.17 D (unaccommodated state). In a subpopulation of 26 young volunteers aged 18 to 33 years, lens dimensions were also measured in an accommodated (6.67 D stimulus) state. For a subpopulation of six of the young volunteers (22 to 33 years), refractive index maps were also acquired with an accommodation stimulus of 6.67 D. RESULTS: Unaccommodated lens thickness increased significantly with age (T = 3.31 +/- 0.10 mm + 0.0180 +/- 0.0036 mm x Age; p < 0.0001). Lens diameter (D = 9.33 +/- 0.0033 mm) and central refractive index (nc = 1.4198 +/- 0.0067) showed no significant age dependence. Lens thickness increased (DeltaT = 0.050 +/- 0.024 mm/D) and diameter decreased (DeltaD = -0.067 +/- 0.030 mm/D) on accommodation. A slight decrease in central refractive index with accommodation was not statistically significant. CONCLUSIONS: The results are consistent with the Helmholtz theory of accommodation.

Impact and interest:

40 citations in Scopus
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37 citations in Web of Science®

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ID Code: 12529
Item Type: Journal Article
Additional Information: Full-text can be freely accessed online via the journal’s web page 12 months after publication.
Additional URLs:
Keywords: eye lens, refractive index, accommodation, MRI, age dependence, OAVJ
ISSN: 1040-5488
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Optical Technology (111302)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Funding:
Copyright Owner: Copyright 2007 Lippincott Williams & Wilkins
Deposited On: 19 Feb 2008
Last Modified: 09 Apr 2014 22:21

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