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The Rod-Mediated Multifocal Electroretinogram in Aging and in Early Age-Related Maculopathy Eyes

Feigl, Beatrix, Brown, Brian, Lovie-Kitchin, Jan E., & Swann, Peter G. (2005) The Rod-Mediated Multifocal Electroretinogram in Aging and in Early Age-Related Maculopathy Eyes. In Annual meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, USA.

Abstract

Purpose:To investigate rod-mediated function with the multifocal electroretinogram (mfERG) in normal subjects and in subjects with early age-related maculopathy (ARM). Methods and subjects: Thirty subjects were tested with the rod-mediated mfERG; 10 healthy young subjects (mean age 31 years) and 10 healthy older subjects (mean age 71 years) formed groups 1 and 2 respectively and 10 early ARM subjects formed group 3 (mean age 71 years). To approximate the influence of cataract, five subjects of group 1 were re-tested with added neutral density filters (0.3 ND) (group 4). The first-order N1P1 amplitude and P1 latency responses were analysed. The unscaled 61 hexagons were averaged into 4 rings to examine topographical differences. Funduscopic and lens changes as defined by Age-Related Eye Disease Study Research Group criteria (AREDS) were correlated with the mfERG parameters. Results: P1 latencies were significantly delayed in groups 2 (p=0.02) and 3 (p<0.001) compared to group 1. Group 3 showed significantly delayed results compared to groups 2 and 4 (p<0.01). In contrast there were no significant differences in N1P1 amplitudes between groups but there was a significant location effect for all groups with highest mean amplitudes for ring 4 (p<0.01). Significantly longer P1 latencies (p<0.05) were related to more advanced fundus changes. Conclusions: The rod-mediated mfERG is affected by aging and early ARM and is correlated with funduscopic changes. Although a preretinal cause cannot be excluded the findings suggest neuronal transmission alterations at the post-receptoral level in aging and in early ARM.

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ID Code: 12534
Item Type: Conference Paper
Additional Information: For more information, please refer to the association’s website (see hypertext link) or contact the author.
Additional URLs:
Keywords: 411 age, related macular degeneration, 413 aging, visual performance, 501 electroretinography, clinical
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Optical Technology (111302)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2005 The Association for Research in Vision and Ophthalmology (ARVO)
Deposited On: 19 Feb 2008
Last Modified: 22 Apr 2010 03:10

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