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A hybrid CA-PDE Model of chlamydia trachomatis infection in the female genital tract

Mallet, Daniel G., Heymer, Kelly-Jean, & Wilson, David P. (2008) A hybrid CA-PDE Model of chlamydia trachomatis infection in the female genital tract. In 6th International Congress on Industrial and Applied Mathematics, 16-20 July 2007, Zurich. (Unpublished)

Abstract

Chlamydia trachomatis is amongst the most common sexually transmitted diseases in the world and when left untreated, may lead to serious sequelae particularly in women such as pelvic inflammatory disease, ectopic pregnancy and infertility. Currently, most mathematical modelling in the literature regarding Chlamydia is based on time dependent differential equations. The serious pathology associated with C. trachomatis occurs when the chlamydial infection ascends to the upper genital tract. But no modelling study has investigated the important spatial aspects of the disease. In this work, we include spatiotemporal considerations of the progression of chlamydial infection in the genital tract. This novel direction is achieved using cellular automata modelling with probabilistic decision processes. In this presentation, the modelling strategy will be described, as well as its relationship with existing models and the advances in understanding that are achieved with such a model. Such an approach provides valuable insights into disease progression and will lead to experimentally testable predictions and a basis for further investigation in this area.

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202 since deposited on 25 Feb 2008
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ID Code: 12623
Item Type: Conference Paper
Additional URLs:
Keywords: chlamydia, mathematics, hybrid CA-PDE model
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > PURE MATHEMATICS (010100)
Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > OTHER MATHEMATICAL SCIENCES (019900) > Mathematical Sciences not elsewhere classified (019999)
Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000)
Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)
Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > PURE MATHEMATICS (010100) > Pure Mathematics not elsewhere classified (010199)
Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > OTHER MATHEMATICAL SCIENCES (019900)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2008 (please consult author)
Deposited On: 25 Feb 2008
Last Modified: 21 Oct 2014 07:29

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