Targeting the nuclear factor kappa-light-chain-enhancer of activated b cells (NF-kb) pathway to overcome cisplatin-resistance in non-small cell lung cancer
Ryan, Sarah-Louise (2019) Targeting the nuclear factor kappa-light-chain-enhancer of activated b cells (NF-kb) pathway to overcome cisplatin-resistance in non-small cell lung cancer. PhD thesis, Queensland University of Technology.
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Sarah-Louise Ryan Thesis
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Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
This project contributed to a greater understanding of chemotherapy resistance in non-small cell lung cancer (NSCLC), a prevalent issue to chemotherapy. The potential of the inflammatory transcription factor NF-ĸB as a therapeutic target was investigated to combat NSCLC chemo-resistance using in vitro and in vivo approaches. The activity of NF-ĸB was elucidated in models of chemo-resistant NSCLC and where specific inhibitors of NF-ĸB were used to block activity. In addition, a novel 3D model of chemo-resistance in NSCLC was generated which will serve as an important model in future studies.
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| ID Code: | 127346 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Adams, Mark, O'Byrne, Ken, Thompson, Rik, & Davies, Anthony |
| Keywords: | Chemokines, Chemo-resistance, Cisplatin, Dehydroxymethylepoxyquinomicin (DHMEQ), Inflammation, Inhibition, Isogenic, Non-small cell lung cancer (NSCLC), Nuclear factor kappa-light-chain-enhancer of activ, Spheroid |
| DOI: | 10.5204/thesis.eprints.127346 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 26 Mar 2019 15:18 |
| Last Modified: | 19 Jan 2025 00:43 |
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