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A randomised controlled study of the efficacy of hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient

Koroloff, Natasha, Boots, Robert, Lipman, Jeff, Thomas, Peter, Rickard, Claire, & Coyer, Fiona M. (2004) A randomised controlled study of the efficacy of hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient. Intensive Care Medicine, 30(6), pp. 1122-1126.

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Abstract

Objective To compare the efficacy of two forms of eye care (hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients. Design Randomised-controlled trial. Setting University affiliated, tertiary referral hospital. Patients and participants One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection. Interventions All patients received standard eye cleansing every 2 h. In addition to this, group one (n=60) received a treatment combining hypromellose drops and Lacri-Lube (HL) to each eye every 2 h. Group two (n=50) had polyethylene covers only placed over the eye to create a moisture chamber. Measurements and results Corneal ulceration was determined using corneal fluorescein stains and mobile slit lamp evaluation, performed daily. No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group. Conclusions Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.

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20 citations in Web of Science®

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ID Code: 1359
Item Type: Journal Article
Keywords: Clinical nursing research, Critical care, Eye, Epithelium, Corneal
DOI: 10.1007/s00134-004-2203-y
ISSN: 1432-1238
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NURSING (111000) > Clinical Nursing - Secondary (Acute Care) (111003)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Springer
Copyright Statement: The original publication is available at SpringerLink http://www.springerlink.com
Deposited On: 20 May 2005
Last Modified: 29 Feb 2012 23:05

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