The effects of Simvastatin on bone healing around titanium implants in osteoporotic rats

Du, Zhibin, Chen, Jiang, Yan, Fuhua, & Xiao, Yin (2009) The effects of Simvastatin on bone healing around titanium implants in osteoporotic rats. Clinical Oral Implants Research, 20(2), pp. 145-150.

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Objective: Osteoporosis is known to impair the process of implant osseointegration. The recent discovery that statins (HMG-CoA reductase inhibitors) act as bone anabolic agents, suggests statins can be used as potential agents in the treatment of osteoporosis. Therefore, we hypothesized that statins will promote osteogenesis around titanium implants in subjects with osteoporosis. Materials and methods: Fifty-four female Sprague Dawley rats, aged 3 months old, were randomly divided into three groups: Sham-operated group (SHAM; n=18); ovariectomized group (OVX; n=18); and ovariectomized with Simvastatin treatment group (OVX+SIM; n=18). 56 days after being ovariectomized (OVX), screw-shaped titanium implants were inserted into the tibiae. Simvastatin was administered orally at 5mg/kg each day after the placement of the implant in the OVX+SIM group. The animals were sacrificed at either 28 or 84 days after implantation and the undecalcified tissue sections were obtained. Bone-to-implant contact (BIC) and bone area (BA) within the limits of implant threads were measured around the cortical (zone A) and cancellous (zone B) bone regions. Furthermore, bone density (BD) of zone B in a 500 µm -wide zone lateral to the implants was also measured. Results: There were no significant differences in BIC and BA measurements in zone A in any of the three groups at either 28 or 84 days after implantation (P>0.05). By contrast, in zone B significant differences in the measurement of BIC, BA, and BD were observed at 28 and 84 days between all three groups. Bone healing decreased with lower BIC, BA and BD around implant in OVX group compared with other two groups and Simvastatin reversed the negative effect of OVX on bone healing around implants with the improvement of BIC, BA, and BD in zone B. Conclusion: Osteoporosis can significantly influence bone healing in the cancellous bone around titanium implants and Simvastatin was shown to significantly improve the osseointegration of pure titanium implants in osteoporotic rats.

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ID Code: 13823
Item Type: Journal Article
Refereed: Yes
DOI: 10.1111/j.1600-0501.2008.01630.x
ISSN: 0905-7161
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > DENTISTRY (110500)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2009 Blackwell Publishing
Copyright Statement: The definitive version is available at
Deposited On: 20 Jun 2008 00:00
Last Modified: 29 Feb 2012 13:57

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