Optimization of allogeneic mesenchymal progenitor cells for posterolateral spinal fusion with posterior instrumentation in sheep
Mulaibrahimovic, Adnan, Oakley, Andrew P., Tizzard, Simon P., LaRue, Bernard, Nikoloff, Steven, de Visser, Hans, Adam, Clayton J., Pearcy, Mark J., Vernon-Roberts, Barrie, Fraser, Robert D., & Moore, Robert J. (2007) Optimization of allogeneic mesenchymal progenitor cells for posterolateral spinal fusion with posterior instrumentation in sheep. In The Adelaide Centre for Spinal Research - Spinal Research Symposium V, 28-30 August 2007, Adelaide, Australia.
Autologous bone is a finite resource and harvesting is associated with significant morbidity. This study investigated the safety and efficacy of allogeneic mesenchymal progenitor cells (MPCs) delivered via a calcium phosphate carrier to stimulate bone growth in spinal fusion compared to autograft control in an ovine model. MPCs promote early development of spinal fusion equivalent to autologous bone graft in this ovine model. Given the potential for significant clinical problems with autologous grafting consideration must be given to using MPCs in this setting.
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|Item Type:||Conference Paper|
|Keywords:||mesenchymal progenitor cells, posterior instrumentation, spinal fusion, autograft, autologous bone|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2007 (please consult author)|
|Deposited On:||24 Jun 2008|
|Last Modified:||10 Aug 2011 18:42|
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