Cardiovascular changes after pulmonary embolism from injecting calcium phosphate cement
Krebs, Jorg, Aebli, Nikolaus, Goss, Benjamin G., Sugiyama, Sadahiro, Bardyn, Thibaut, Boecken, Ilka, Leamy, Patrick J., & Ferguson, Stephen J. (2007) Cardiovascular changes after pulmonary embolism from injecting calcium phosphate cement. Journal of Biomedical Materials Research B: Applied Biomaterials, 82B(2), pp. 526-532.
Concerns have been raised that the use of calcium phosphate (CaP) cements for the augmentation of fractured, osteoporotic bones may aggravate cardiovascular deterioration in the event of pulmonary cement embolism by stimulating coagulation. The aim of the present study was therefore to investigate the cardiovascular changes after pulmonary embolism of CaP cement using an animal model. In 14 sheep, 2.0 mL CaP or polymethylmethacrylate cement were injected intravenously. Cardiovascular parameters and antithrombin levels were monitored until 60 min postinjection. Postmortem, lungs were subjected to CT scanning, and 3D reconstruction of the cement was performed. Intravenous injection of CaP cement resulted in a more severe increase in pulmonary arterial pressure and decrease in arterial blood pressure. Disintegration of the CaP cement seemed to be the reason for the more severe reaction. There was no evidence of thromboembolism. Disintegration of CaP cement in circulating blood does not only compromise the mechanical properties, but also represents a risk of cardiovascular complications. Reliable cohesion of CaP cements in an aqueous environment is essential for clinical applications such as osteoporotic bone augmentation. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007
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|Item Type:||Journal Article|
|Additional Information:||Self-archiving of the author-version in institutional repositories is not currently supported by this publisher. For more information, please refer to the journal's website (see hypertext link) or contact the author.|
|Keywords:||calcium phosphate cement, pulmonary cement embolism, coagulation, cardiovascular complications, polymethylmethacrylate|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering|
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2007 John Wiley & Sons|
|Deposited On:||27 Oct 2008|
|Last Modified:||14 Oct 2013 11:50|
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