Inhomogeneous NMR line shape as a probe of microscopic organization of bicontinuous cubic phases
Momot, Konstantin I., Takegoshi, Kiyonori, Kuchel, Philip W., & Larkin, Timothy J. (2008) Inhomogeneous NMR line shape as a probe of microscopic organization of bicontinuous cubic phases. Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces and Biophysical, 112(21), pp. 6636-6645.
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NMR line shapes of the lipid and aqueous species in bicontinuous cubic phase (BCP) samples prepared by centrifugation are inhomogeneously broadened. The broadening of the lipid peaks is removed by magic-angle spinning (MAS). In this work, we studied the mechanism of this broadening using 1H and 13C NMR spectroscopy of a Myverol/water BCP. It is demonstrated that the inhomogeneity possesses an intrinsic contribution that is independent of instrumental or setup factors and can be attributed to the microscopic organization of the BCP bilayer. A mechanism of the inhomogeneous broadening is proposed, which involves a spatially non-uniform diamagnetically induced magnetic field determined by the mesoscopic structure and the diamagnetic susceptibilities of the two BCP domains. The proposed mechanism does not require that molecular reorientation of the lipid be slow for the inhomogeneous broadening to survive. We discuss, how this inhomogeneous broadening can be employed as a probe of compositional uniformity and microscopic organization of BCP samples.
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|Item Type:||Journal Article|
|Additional Information:||This article is freely available from the American Chemical Society website 12 months after the publication date. See links to publisher website in this record.|
|Keywords:||lipid bilayer, bicontinuous cubic phases, molecular mobility in the bilayer, induced magnetic field, inhomogeneous broadening, diamagnetic susceptibility|
|Subjects:||Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > PHYSICAL CHEMISTRY (INCL. STRUCTURAL) (030600) > Physical Chemistry not elsewhere classified (030699)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
|Copyright Owner:||Copyright 2008 American Chemical Society|
|Deposited On:||14 Aug 2008|
|Last Modified:||29 Feb 2012 23:48|
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