Bilayered scaffolds for osteochondral tissue engineering

O'Shea, Timothy M. & Miao, Xigeng (2008) Bilayered scaffolds for osteochondral tissue engineering. Tissue Engineering Part B: Reviews, 14(4), pp. 447-464.

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Osteoarthritis (OA) is a prevalent degenerative joint disease that places a significant burden on the socioeconomic efficacy of communities around the world. Tissue engineering repair of articular cartilage in synovial joints represents a potential OA treatment strategy superior to current surgical techniques. In particular, osteochondral tissue engineering, which promotes the simultaneous regeneration of articular cartilage and underlining subchondral bone may be a clinically relevant approach towards impeding OA progression. The unique and complex functional demands of the two contrasting tissues that comprise osteochondral tissue require the use of bilayered scaffolds to promote individual growth of both on a single integrated implant. This paper reviews the three current bilayered scaffold strategies applied to solve this challenging problem, with a focus on the need for an innovative approach to design and fabrication of new optimized scaffold combinations in order to reinforce materials science as an important element of osteochondral tissue engineering.

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ID Code: 14467
Item Type: Journal Article
Refereed: Yes
Additional Information: Self-archiving of the author-version is not yet supported by this publisher.
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DOI: 10.1089/ten.teb.2008.0327
ISSN: 1076-3279
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Copyright Owner: Copyright 2008 Mary Ann Liebert, Inc.
Deposited On: 22 Aug 2008 00:00
Last Modified: 06 Nov 2013 15:56

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