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The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans

Voisey, Joanne, Swagell, Christopher D., Hughes, Ian P., Morris, C. Phillip, van Daal, Angela M., Noble, Earnest P., Kann, Burnett, Heslop, Karen A., Young, Ross McD., & Lawford, Bruce R. (2008) The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans. Depression and Anxiety, 26(1), pp. 28-33.

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Abstract

Background: Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatric disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C>T) and a deletion polymorphism (-141delC) in the DRD2 gene and a SNP (Taq1A) in a gene directly downstream of DRD2 have all been implicated in dopamine functioning in the brain. Methods: To test the importance of these three polymorphisms in PTSD susceptibility, a genetic screen was performed in 127 war veterans diagnosed with PTSD and 228 control individuals without a history of PTSD. Results: No significant association was found between PTSD and the Taq1A or -141delC polymorphisms. However, a significant association was observed with PTSD and the 957C>T polymorphism. PTSD individuals were more likely to carry the C allele compared to the controls (P=0.021). Conclusions: Our findings suggest that the 957C>T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD. Depression Anxiety 0:1-6, 2008. (c) 2008 Wiley-Liss, Inc.

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ID Code: 14823
Item Type: Journal Article
Additional Information: The definitive version is available at www3.interscience.wiley.com
Additional URLs:
DOI: 10.1002/da.20517
ISSN: 1091-4269
Subjects: Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Health Clinical and Counselling Psychology (170106)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Genome Structure and Regulation (060407)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Genetics not elsewhere classified (060499)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 John Wiley & Sons
Deposited On: 06 Oct 2008
Last Modified: 29 Feb 2012 23:49

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