The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans
Voisey, Joanne, Swagell, Christopher D., Hughes, Ian P., Morris, C. Phillip, van Daal, Angela M., Noble, Earnest P. , Kann, Burnett , Heslop, Karen A., Young, Ross McD., & Lawford, Bruce R. (2008) The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans. Depression and Anxiety, 26(1), pp. 28-33.
Background: Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatric disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C>T) and a deletion polymorphism (-141delC) in the DRD2 gene and a SNP (Taq1A) in a gene directly downstream of DRD2 have all been implicated in dopamine functioning in the brain. Methods: To test the importance of these three polymorphisms in PTSD susceptibility, a genetic screen was performed in 127 war veterans diagnosed with PTSD and 228 control individuals without a history of PTSD. Results: No significant association was found between PTSD and the Taq1A or -141delC polymorphisms. However, a significant association was observed with PTSD and the 957C>T polymorphism. PTSD individuals were more likely to carry the C allele compared to the controls (P=0.021). Conclusions: Our findings suggest that the 957C>T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD. Depression Anxiety 0:1-6, 2008. (c) 2008 Wiley-Liss, Inc.
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|Item Type:||Journal Article|
|Additional Information:||The definitive version is available at www3.interscience.wiley.com|
|Subjects:||Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Health Clinical and Counselling Psychology (170106)|
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Genome Structure and Regulation (060407)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Genetics not elsewhere classified (060499)
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2008 John Wiley & Sons|
|Deposited On:||06 Oct 2008|
|Last Modified:||29 Feb 2012 23:49|
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