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Identification of drugs that interact with herbs in drug development

Zhou, Shu-Feng, Zhou, Zhi-Wei, Li, Chun-Guang, Chen, Xiao, Yu, Xiyong, Xue, Charlie Changli, & Herington, Adrian (2007) Identification of drugs that interact with herbs in drug development. Drug Discovery Today, 12(15-16), pp. 664-673.

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Abstract

To date, several clinically important drugs have been identified that interact with commonly used herbs. These drugs include (among others) warfarin, midazolam, digoxin, amitriptyline, indinavir, cyclosporine, tacrolimus and irinotecan. Importantly, many of these drugs have very narrow therapeutic indices. Most of them are substrates for cytochrome P450s (CYPs) and/or P-glycoprotein (P-gp). Because drug–herb interactions can significantly affect circulating levels of drug and, hence, alter the clinical outcome, the identification of drugs that interact with commonly used herbal medicines has important implications in drug development. In silico, in vitro, animal and human studies are often used to identify drug interactions with herbs. We propose that drug–herb and herb–CYP interaction studies should be incorporated into drug development.

Because of the clinical significance of drug interactions with herbs, there is a strong necessity to identify drugs that may interact with herbal medicines in drug development.

Impact and interest:

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55 citations in Web of Science®

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ID Code: 14827
Item Type: Journal Article
DOI: 10.1016/j.drudis.2007.06.004
ISSN: 1359-6446
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Basic Pharmacology (111501)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > COMPLEMENTARY AND ALTERNATIVE MEDICINE (110400) > Traditional Chinese Medicine and Treatments (110404)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Elsevier
Copyright Statement: Reproduced in accordance with the copyright policy of the publisher.
Deposited On: 12 Sep 2008
Last Modified: 09 Jun 2010 23:04

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