Intramolecular interactions in aminoacyl cyclic-3',5'-nucleotides
Polymerization of amino-acid acyl cyclic-3',5'-nucleotides is postulated to be the origin of RNA and associated protein in prebiotic molecular evolution. The enthalpy change in the intramolecular interaction between the nucleotide base and the amino-acid side chain determines the stability of the particular complex, resulting in a preferred association (or coding) of a base for a particular amino acid. The compounds studied were glycine acyl cyclic-3',5'-guanylate where the strong hydrogen bond between protonated glycine and guanine N7 gives an enthalpy change of −0.05 h. Similarly, hydrogen bonds in l-lysine acyl cyclic-3',5'-adenylate give an enthalpy change of −0.06 h. Hydrophobic interactions in l-phenylalanine acyl cyclic-3',5'-uridylate give an enthalpy change of −0.02 h and the corresponding value for l-proline acyl cyclic-3',5'-cytidylate is −0.01 h. These interactions were expected to be modified as the genetic code became a duplet and finally a triplet code.
The interactions have been shown to be feasible from the overall enthalpy changes in the ZKE approximation at the MP2/6-31G* level.
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|Item Type:||Journal Article|
|Additional Information:||For more information, please refer to the journal's website (see hypertext link) or contact the author.|
|Keywords:||Amino, acid acyl cyclic, 3′, 5′, nucleotides of guanylic acid and glycine, Adenylic acid and l, lysine, Uridylic acid and l, phenylalanine, Cytidylic acid and l, proline, Genetic code|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
|Copyright Owner:||Copyright 2007 Elsevier|
|Deposited On:||14 Oct 2008|
|Last Modified:||29 Feb 2012 23:41|
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