Amphiphilic Triblock Copolymers of Methoxy-Poly(ethylene glycol)-b- Poly(L-lactide)-b-Poly(L-lysine) for Enhancement of Osteoblast Attachment and Growth

Peng, Hui, Xiao, Yin, Mao, Xueli, Chen, Lan, Crawford, Ross W., & Whittaker, Andrew (2009) Amphiphilic Triblock Copolymers of Methoxy-Poly(ethylene glycol)-b- Poly(L-lactide)-b-Poly(L-lysine) for Enhancement of Osteoblast Attachment and Growth. Biomacromolecules, 10(1), pp. 95-104.

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Abstract: Amphiphilic triblock copolymers of methoxy-poly(ethylene glycol)–poly(L-lactide)–poly(Llysine) (MPEG-b-PLLA-b-PLL) (Mn=8540-22240) were synthesized through the ring-opening polymerization of Nε-(Z)-lysine-N-carboxyanhydrides (Nε-(Z)-Lys-NCA) using MPEG–b-PLLA-NH2 as macroinitiator. The triblock copolymers and diblock precursors were characterized by 1H NMR, ATR-FTIR and GPC. The chain lengths of each block could be controlled by varying the feed ratios of the monomers. The surface properties of films of PLLA modified by blending with the triblock copolymers were investigated by XPS and AFM, and demonstrated an enrichment of PLL blocks on the surface of the PLLA film. No cytotoxicity was detected on a range of modified PLLA films arising from the incorporation of the triblock copolymers. The triblock copolymers MPEG-b-PLLA-b-PLL showed better surface properties in promoting osteoblast adhesion and proliferation compared to pure PLLA and to PLLA modified with MPEG–b-PLLA diblock copolymers. This study demonstrated that the triblock copolymers containing free amino groups, which self-segregate on the surface of biodegradable polyesters, have potential for applications in cell delivery and tissue engineering.

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ID Code: 15495
Item Type: Journal Article
Refereed: Yes
Additional Information: This article is freely available from the American Chemical Society website 12 months after the publication date. See links to publisher website in this record.
Additional URLs:
ISSN: 1525-7797
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2009 American Chemical Society
Deposited On: 06 Nov 2008 00:00
Last Modified: 29 Feb 2012 13:54

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