QUT ePrints

Amphiphilic Triblock Copolymers of Methoxy-Poly(ethylene glycol)-b- Poly(L-lactide)-b-Poly(L-lysine) for Enhancement of Osteoblast Attachment and Growth

Peng, Hui, Xiao, Yin, Mao, Xueli, Chen, Lan, Crawford, Ross W., & Whittaker, Andrew (2009) Amphiphilic Triblock Copolymers of Methoxy-Poly(ethylene glycol)-b- Poly(L-lactide)-b-Poly(L-lysine) for Enhancement of Osteoblast Attachment and Growth. Biomacromolecules, 10(1), pp. 95-104.

[img] PDF (1MB)
Administrators only | Request a copy from author

Abstract

Abstract: Amphiphilic triblock copolymers of methoxy-poly(ethylene glycol)–poly(L-lactide)–poly(Llysine) (MPEG-b-PLLA-b-PLL) (Mn=8540-22240) were synthesized through the ring-opening polymerization of Nε-(Z)-lysine-N-carboxyanhydrides (Nε-(Z)-Lys-NCA) using MPEG–b-PLLA-NH2 as macroinitiator. The triblock copolymers and diblock precursors were characterized by 1H NMR, ATR-FTIR and GPC. The chain lengths of each block could be controlled by varying the feed ratios of the monomers. The surface properties of films of PLLA modified by blending with the triblock copolymers were investigated by XPS and AFM, and demonstrated an enrichment of PLL blocks on the surface of the PLLA film. No cytotoxicity was detected on a range of modified PLLA films arising from the incorporation of the triblock copolymers. The triblock copolymers MPEG-b-PLLA-b-PLL showed better surface properties in promoting osteoblast adhesion and proliferation compared to pure PLLA and to PLLA modified with MPEG–b-PLLA diblock copolymers. This study demonstrated that the triblock copolymers containing free amino groups, which self-segregate on the surface of biodegradable polyesters, have potential for applications in cell delivery and tissue engineering.

Impact and interest:

24 citations in Scopus
Search Google Scholar™
21 citations in Web of Science®

Citation countsare sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 15495
Item Type: Journal Article
Additional Information: This article is freely available from the American Chemical Society website 12 months after the publication date. See links to publisher website in this record.
Additional URLs:
ISSN: 1525-7797
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2009 American Chemical Society
Deposited On: 06 Nov 2008
Last Modified: 29 Feb 2012 23:54

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page