Apoptosis of tumour cells by temperature and anti-tumour drug: microscopic and macroscopic investigations
Lia, Li, Tian, Yu-Chu, Tade, Moses O., Feng, Y., & Qu, S. S. (2003) Apoptosis of tumour cells by temperature and anti-tumour drug: microscopic and macroscopic investigations. Journal of Thermal Biology, 28(4), pp. 321-329.
Human ovarian carcinoma cell line (COCL) behaves differently under different temperatures and/or anti-tumour drug Carmofur levels, which result in metabolic and ultrastructural changes of the tumour cells. The technique of microcalorimetry is adopted to investigate the metabolic behaviour of the tumour cells; while the technique of transmission electron microscopy is used to detect cells' ultrastructural changes. Quantitative analysis is also performed through image processing. The mechanisms of hyperthermia and chemotherapy in treatment of tumour cells are explored at both macroscopic and microscopic levels. It is shown that a high temperature reduces metabolic activity of the tumour cells, appears to cause both apoptosis and necrosis in COCL, and results in a series of malignant changes in the cell morphology. The concurrent application of hyperthermia and chemotherapy can speed up the apoptosis of the tumour cells and reduce cells' metabolic power. A sustained and longer action of such a concurrent application will lead to ultimate death of the tumour cells.
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|Item Type:||Journal Article|
|Additional Information:||For more information, please refer to the journal’s website (see hypertext link) or contact the author.|
|Keywords:||hyperthermia, microcalorimetry, TEM, apoptosis, tumour cells, HAMSTER OVARY CELLS, HEAT, SHOCK, HYPERTHERMIA, CANCER, DEATH, LINE, THERMOSENSITIVITY, DESTABILIZATION, CYTOSKELETON, DENATURATION|
|Subjects:||Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > MEDICINAL AND BIOMOLECULAR CHEMISTRY (030400) > Medicinal and Biomolecular Chemistry not elsewhere classified (030499)
Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Synchrotrons; Accelerators; Instruments and Techniques (029904)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Biochemistry and Cell Biology not elsewhere classified (060199)
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
|Copyright Owner:||Copyright 2003 Elsevier Science Ltd.|
|Copyright Statement:||NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Thermal Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Thermal Biology, Volume 28, Issue 4, May 2003, DOI: 10.1016/S0306-4565(03)00008-1|
|Deposited On:||25 Jan 2008|
|Last Modified:||19 Dec 2014 00:55|
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