Apoptosis of tumour cells by temperature and anti-tumour drug: microscopic and macroscopic investigations
Lia, Li, Tian, Yu-Chu, Tade, Moses O. , Feng, Y., & Qu, S. S. (2003) Apoptosis of tumour cells by temperature and anti-tumour drug: microscopic and macroscopic investigations. Journal of Thermal Biology, 28(4), pp. 321-329.
Human ovarian carcinoma cell line (COCL) behaves differently under different temperatures and/or anti-tumour drug Carmofur levels, which result in metabolic and ultrastructural changes of the tumour cells. The technique of microcalorimetry is adopted to investigate the metabolic behaviour of the tumour cells; while the technique of transmission electron microscopy is used to detect cells' ultrastructural changes. Quantitative analysis is also performed through image processing. The mechanisms of hyperthermia and chemotherapy in treatment of tumour cells are explored at both macroscopic and microscopic levels. It is shown that a high temperature reduces metabolic activity of the tumour cells, appears to cause both apoptosis and necrosis in COCL, and results in a series of malignant changes in the cell morphology. The concurrent application of hyperthermia and chemotherapy can speed up the apoptosis of the tumour cells and reduce cells' metabolic power. A sustained and longer action of such a concurrent application will lead to ultimate death of the tumour cells.
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