Numerical Sequence Representation of DNA Sequences and Methods To Distinguish Coding And Non-Coding Sequences in a Complete Genome
Yu, Zuguo, Anh, Vo V., Zhou, Yu, & Zhou, Li-Qian (2007) Numerical Sequence Representation of DNA Sequences and Methods To Distinguish Coding And Non-Coding Sequences in a Complete Genome. In Callaos, N., Lesso, W., Zinn, C., & Zmazek, B. (Eds.) 11th World Multi-Conference on Systemics, Cybernetics and Informatics: WMSCI 2007, 8-11 July 2007, Florida, USA.
In this presentation we introduce two methods to distinguish coding and non-coding sequences in a complete genome. A numerical sequence representation of DNA sequences is introduced first.
There exists a one-to-one correspondence between a DNA sequence and its numerical sequence representation. In the first method, three exponents from a multifractal analysis are selected to construct the parameter space. In the second method, which is
based on a Fourier transform approach, three parameters from the power spectrum of the numerical sequence representation are selected to construct the parameter space. Each DNA may be represented by a point in these three-dimensional spaces. We found that
the points corresponding to coding and non-coding sequences in the complete genomes of prokaryotes are divided into different regions in both parameter spaces. If the point for a DNA sequence is situated in the region corresponding to coding sequences, the
sequence is recognized as a coding sequence; otherwise, the sequence is classified as a non-coding one. The average accuracies using Fisher's discriminant algorithm for coding and non-coding sequences are satisfactory.
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|Item Type:||Conference Paper|
|Subjects:||Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)|
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Genome Structure and Regulation (060407)
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
|Copyright Owner:||Copyright 2007 (please consult author)|
|Deposited On:||18 Nov 2008|
|Last Modified:||29 Feb 2012 23:40|
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