Effect of a long and short acting beta two-agonist on exercise-induced arterial hypoxemia
Stewart, Ian B., LaBreche, Jane M., & McKenzie, Donald C. (2003) Effect of a long and short acting beta two-agonist on exercise-induced arterial hypoxemia. Medicine and Science in Sports and Exercise, 35(4), pp. 603-607.
Purpose: To determine the effect of formoterol and salbutamol on the arterial oxygen saturation (SaO2) of highly trained nonasthmatic athletes with exercise-induced arterial hypoxemia (EIAH). Methods: Ten male athletes (age 27.1 0.7, V˙ O2max 65.2 2.5 mL·kg1·min1, SaO2min 91.0 2.1%) with minimal bronchial reactivity to aerosols (i.e., negative methacholine challenge test) completed three identical exercise sessions differing only by the medication administered. Formoterol (F), a long-acting -2 agonist, was compared with salbutamol (S) and a placebo (P). F (12 g), S (400 g), or P was administered by a Turbuhaler, 10 min before exercise testing in a double-blind, randomized, three-way crossover design. Testing sessions included an incremental cycle ergometer test to exhaustion, while monitoring SaO2 and ventilation, and a pre- and postexercise pulmonary function test. Results: There were no significant differences between the groups in SaO2 nadir with exercise (F 92.0 1.0; S 92.0 1.0; P 91.0 0.7%). During the maximal incremental test, no differences were observed in SaO2 or minute ventilation between the three experimental conditions. Pulmonary function tests revealed a significant increase in FEV1 and FEV1/FVC after exercise in all conditions. Drug administration increased FEV1/FVC postexercise compared with placebo (F 87.9 2.3, S 87.6 1.7 P 85.6 2.1%; P 0.05). Conclusion: An acute, inhaled, therapeutic dose of formoterol or salbutamol did not affect SaO2 nadir or ventilation kinetics in a group of highly trained nonasthmatic athletes with EIAH.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Additional Information:||Self-archiving of the author-version is not yet supported by this publisher. For more information, please refer to the journal's website (see link) or contact the author. Author contact details: Ian Stewart email@example.com|
|Keywords:||BRONCHODILATOR, ARTERIAL OXYGEN SATURATION, NONASTHMATIC, ATHLETE|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
|Copyright Owner:||Copyright 2003 Lippincott Williams and Wilkins|
|Deposited On:||16 Jun 2005 00:00|
|Last Modified:||10 Aug 2011 16:04|
Repository Staff Only: item control page