Effect of a long and short acting beta two-agonist on exercise-induced arterial hypoxemia

Stewart, Ian B., LaBreche, Jane M., & McKenzie, Donald C. (2003) Effect of a long and short acting beta two-agonist on exercise-induced arterial hypoxemia. Medicine and Science in Sports and Exercise, 35(4), pp. 603-607.

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Purpose: To determine the effect of formoterol and salbutamol on the arterial oxygen saturation (SaO2) of highly trained nonasthmatic athletes with exercise-induced arterial hypoxemia (EIAH). Methods: Ten male athletes (age 27.1 0.7, V˙ O2max 65.2 2.5 mL·kg1·min1, SaO2min 91.0 2.1%) with minimal bronchial reactivity to aerosols (i.e., negative methacholine challenge test) completed three identical exercise sessions differing only by the medication administered. Formoterol (F), a long-acting -2 agonist, was compared with salbutamol (S) and a placebo (P). F (12 g), S (400 g), or P was administered by a Turbuhaler, 10 min before exercise testing in a double-blind, randomized, three-way crossover design. Testing sessions included an incremental cycle ergometer test to exhaustion, while monitoring SaO2 and ventilation, and a pre- and postexercise pulmonary function test. Results: There were no significant differences between the groups in SaO2 nadir with exercise (F 92.0 1.0; S 92.0 1.0; P 91.0 0.7%). During the maximal incremental test, no differences were observed in SaO2 or minute ventilation between the three experimental conditions. Pulmonary function tests revealed a significant increase in FEV1 and FEV1/FVC after exercise in all conditions. Drug administration increased FEV1/FVC postexercise compared with placebo (F 87.9 2.3, S 87.6 1.7 P 85.6 2.1%; P 0.05). Conclusion: An acute, inhaled, therapeutic dose of formoterol or salbutamol did not affect SaO2 nadir or ventilation kinetics in a group of highly trained nonasthmatic athletes with EIAH.

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ID Code: 1603
Item Type: Journal Article
Refereed: Yes
Additional Information: Self-archiving of the author-version is not yet supported by this publisher.
For more information, please refer to the journal's website (see link) or contact the author. Author contact details:
Ian Stewart i.stewart@qut.edu.au
Additional URLs:
ISSN: 1530-0315
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2003 Lippincott Williams and Wilkins
Deposited On: 16 Jun 2005 00:00
Last Modified: 10 Aug 2011 16:04

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