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Cardiovascular and splenic responses to exercise in humans

Stewart, Ian B., Warburton, Darren E.R. , Hodges, Alastair N.H. , & McKenzie, Donald C. (2003) Cardiovascular and splenic responses to exercise in humans. Journal of Applied Physiology, 94(4), pp. 1619-1626.

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Abstract

To investigate splenic erythrocyte volume after exerciseand the effect on hematocrit- and hemoglobin-basedplasma volume equations, nine men cycled at an intensity of60% maximal O2 uptake for 5-, 10-, or 15-min duration,followed by an incremental ride to exhaustion. The reductionin spleen volume, calculated using 99mTc-labeled erythrocytes,was not significantly different among the three submaximalrides (5 min 28%, 10 min 30%, 15 min 36%;P 0.26). The incremental ride to exhaustion resulted in a56% reduction in spleen volume, which recovered to baselinelevels within 20 min. Plasma catecholamines were inverselyrelated to spleen volume after exercise (r 0.70–0.84; P 0.0001). There were no differences in red cell or total blood volume pre- to postexercise; however, a significant reduction in plasma volume was observed (18.9%; P 0.01). There was no difference between the iodinated albumin and the hematocritand hemoglobin methods of assessing plasma volume changes. These results suggest that the spleen regulates its volume in response to an intensity-dependent signal, andplasma catecholamines appear partially responsible. Splenic release of erythrocytes has no effect on indirect measures of plasma volume.

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29 citations in Web of Science®

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ID Code: 1604
Item Type: Journal Article
Additional Information: Self-archiving of the author-version is not yet supported by this publisher. For more information, please refer to the journal’s website (see link) or contact the author. Author contact details: Ian Stewart i.stewart@qut.edu.au
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Keywords: spleen, plasma volume, hematocrit, hemoglobin, plasma catecholamines
DOI: 10.1152/japplphysiol.00040.2002
ISSN: 1522-1601, 8750-7587
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2003 American Physiological Society
Deposited On: 16 Jun 2005
Last Modified: 29 Feb 2012 22:59

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