The impact of carboxy nitroxide antioxidants on irradiated ataxia telangiectasia cells
Hosokawa, Kazuyuki, Chen, Philip, Lavin, Martin, & Bottle, Steven E. (2004) The impact of carboxy nitroxide antioxidants on irradiated ataxia telangiectasia cells. Free Radical Biology and Medicine, 37(7), pp. 946-952.
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Abstract
Three water-soluble carboxy nitroxide antioxidants, 5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl, 4-carboxy-2,2,6,6-tetramethylpiperidin-1-yloxyl, and 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl, show significant impact on the postirradiation survival rates of ataxia telangiectasia (A-T) cells compared to normal cells, an assay which represents a model for understanding the impact of ROS damage on the A-T phenotype. The effects of these antioxidants are much more significant than those of vitamin E or Trolox (a water-soluble vitamin E analog), studied using the same cell survival model
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| ID Code: | 1668 |
|---|---|
| Item Type: | Journal Article |
| Keywords: | Nitroxide, Ataxia telangiectasia, Antioxidant, ROS, Free radical, Oxidative stress |
| DOI: | 10.1016/j.freeradbiomed.2004.06.035 |
| ISSN: | 0891-5849 |
| Subjects: | Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Science and Technology |
| Copyright Owner: | Copyright 2004 Elsevier |
| Copyright Statement: | Reproduced in accordance with the copyright policy of the publisher. |
| Deposited On: | 11 Oct 2005 |
| Last Modified: | 29 Feb 2012 23:09 |
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