Identification of novel serological markers for the diagnosis of inflammatory bowel disease

Collet, Trudi, Huygens, Flavia, & Radford-Smith, Grahame (2008) Identification of novel serological markers for the diagnosis of inflammatory bowel disease. In Australian Gastroenterology Week, 22–25 October 2008, Brisbane, QLD.

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Inflammatory bowel disease (IBD) is heterogeneous and comprised of two main forms of chronic intestinal inflammation, Crohn’s disease (CD) and Ulcerative colitis (UC). At present, several autoantibodies are implicated in IBD with varying levels of sensitivity and specificity for CD and UC. Consequently, using a proteomic approach, we attempted to identify novel bacterial antigens that could potentially discriminate between CD, UC and Indeterminate colitis (IC). Established proteomic methods were used. Serum samples from CD (n = 14), UC (n = 14), IC (n = 8) and Unaffected relative (C) (n = 8) patient groups were obtained. Protein extracts derived from four commensal bacteria (denoted B1, B2, B3 and B4) were probed by sera from each patient group. In each Western blot, the presence of unique bands not present in the unaffected relative control group were identified and subsequently categorised as differential. The predictive and discriminatory potential of the differential target antigens were also evaluated. Significant differences in protein profiles between all disease groups and controls were identified. These preliminary results have identified novel markers that are highly sensitive and specific for the discrimination of IBD.

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ID Code: 17305
Item Type: Conference Paper
Refereed: Yes
Additional Information: Abstract published in Journal of Gastroenterology and Hepatology, 23(supp 4), pp.A215.
Keywords: Inflammatory, Bowel, Disease, Serological, Markers, Trudi Armitage
DOI: 10.1111/j.1440-1746.2008.05611.x
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Gastroenterology and Hepatology (110307)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Life Sciences
Copyright Owner: Copyright 2008 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
Copyright Statement: The definitive version is available on publication at
Deposited On: 03 Feb 2009 02:05
Last Modified: 27 Feb 2014 23:59

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