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Methicillin-susceptible, non-multiresistant methicillin-resistant and multiresistant methicillin-resistant Staphylococcus aureus infections: a clinical, epidemiological and microbiological comparative study

Munckhof, Wendy, Nimmo, Graeme R., Carney, J, Schooneveldt, Jacqueline, Huygens, Flavia, Inman-Bamber, John, Tong, Edward, Morton, Anne-Louise, & Giffard, Philip M. (2008) Methicillin-susceptible, non-multiresistant methicillin-resistant and multiresistant methicillin-resistant Staphylococcus aureus infections: a clinical, epidemiological and microbiological comparative study. European Journal of Clinical Microbiology & Infectious Diseases, 27(5), pp. 355-364.

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Abstract

Abstract Non-multiresistant methicillin-resistant Staphylococcus aureus (nmMRSA) infections are emerging worldwide and are often community-associated. This prospective case–cohort study compares features of 96 nmMRSA clinical isolates with 96 matched multiresistant MRSA (mMRSA) and 192 matched methicillin-susceptible S. aureus (MSSA) clinical isolates. Seventy-four percent of nmMRSA infections were healthcare-associated. nmMRSA infections were much more likely to involve skin and soft tissue (skin and soft tissue infections; SSTIs) and were much less likely to be treated appropriately with antibiotics than MSSA or mMRSA infections. Panton-Valentine leukocidin (PVL) genes were detected in 55% of nmMRSA, 16% of MSSA and 2% of mMRSA isolates. Independent of the methicillin-resistance phenotype, 59% of PVL-positive SSTIs presented as furunculosis compared to only 10% of PVL-negative SSTIs. Patients with PVLpositive infections were much younger than patients with PVL-negative infections. The proportion of PVL-positive infections peaked in the 10–29 years old age group, followed by a linear decline.

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40 citations in Scopus
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36 citations in Web of Science®

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ID Code: 17316
Item Type: Journal Article
Additional Information: Self-archiving of the publisher-version is not yet supported by this publisher. For more information, please refer to the journal’s website (see hypertext link) or contact the author.
Keywords: Staphylococcus aureus, infections, methicillin-resistant, comparative, study
DOI: 10.1007/s10096-007-0449-3
ISSN: 0934-9723
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Clinical Microbiology (110303)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Infectious Diseases (110309)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Infectious Agents (060502)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 Springer
Deposited On: 03 Feb 2009 14:57
Last Modified: 29 Feb 2012 23:45

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