Overconsumption and obesity : Peptides and susceptibility to weight gain
Blundell, J.E., Levin, F., King, Neil A., Barkeling, B., Gustafson, T., Hellstrom, P.M., Holst, J.J., & Naslund, E. (2008) Overconsumption and obesity : Peptides and susceptibility to weight gain. Regulatory Peptides, 149(1-3), pp. 32-38.
Physiological control of feeding is mediated by tonic and episodic signalling systems. These are sometimes thought of as long-term and short-term control. Tonic signals arise from tissue stores whereas episodic signals oscillate periodically with the consumption of food. These physiological controls are paralleled in the motivation to eat by long-acting enduring traits (such as disinhibition) and by short-acting states (such as hunger). Peptides are usually envisaged to exert an action on appetite control through the modulation of states such as hunger and satiety (fullness). Here we provide evidence that peptides involved in tonic regulation — such as leptin — may express a control over appetite motivation through an effect on traits that confer a constant readiness to eat, whereas episodic peptides such as GLP-1 influence appetite motivation through a state such as hunger. The distinction between tonic and episodic regulation, and between traits and states has implications for understanding overconsumption and the susceptibility to weight gain.
Impact and interest:
Citation countsare sourced monthly fromand citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
Current > Schools > School of Exercise & Nutrition Sciences
|Copyright Statement:||© 2008 Elsevier B.V. All rights reserved.|
|Deposited On:||14 Apr 2009 15:05|
|Last Modified:||29 Feb 2012 23:43|
Repository Staff Only: item control page