Obesity, leanness, and mortality : effect modification by physical activity in men and women

Heitmann, Berit L., Hills, Andrew P., & Frederiksen, Peder (2008) Obesity, leanness, and mortality : effect modification by physical activity in men and women. Obesity, 17(1), pp. 136-142.

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The 13-year mortality from BMI, body fat (BF), and fat-free mass (FFM) was examined among active and sedentary adults. In total, 2,819 men and women aged 35–65 years in 1987/1988, participating in the Danish MONICA project, were included, and followed for 13.6 years for total mortality. In men, physical activity modified the health hazard of both a high and a low BMI, and the U-shaped association disappeared among the active (hazard ratio (HR) = 0.86, CI: 0.72–1.02). Among active men, FFM was inversely related to mortality (HR = 0.55, 95% CI: 0.40–0.77) whereas a direct positive trend was seen for BF. Among women, physical activity modified association between BMI and mortality, but the U-shaped association remained among the active. Among women, no significant associations were found between either BF or FFM and total mortality. All effects were independent of waist- and hip-circumferences. In conclusion, among men, physical activity may play an important role for the prevention of early mortality beyond its direct effects, by modifying the health hazard of both a high and a low BMI, and by lowering the risk associated with a high BF or a low FFM. Among women physical activity lowers mortality, but an effect-modifying potential of physical activity on associations between BMI or body composition could not be identified.

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ID Code: 18457
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Obesity, Leanness, Physical activity, Mortality
DOI: 10.1038/oby.2008.479
ISSN: 19307381
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NUTRITION AND DIETETICS (111100) > Nutrition and Dietetics not elsewhere classified (111199)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 14 Apr 2009 04:50
Last Modified: 29 Feb 2012 13:50

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