Controlled release of an antibiotic, gentamicin sulphate, from gravity spun polycaprolactone fibers

Chang, H.I., Lau, Y.C., Yan, Cheng, & Coombes, Alan (2008) Controlled release of an antibiotic, gentamicin sulphate, from gravity spun polycaprolactone fibers. Journal of Biomedical Materials Research Part A, 84A(1), pp. 230-237.

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The antibiotic, gentamicin sulphate (GS), was incorporated in gravity-spun polycaprolactone (PCL) fibers by spinning from particulate suspensions of the drug in PCL solution to produce a controlled delivery system. The production rate of GS-loaded PCL fibers was confined to the range 1–1.5 m/min and the fiber diameter to 170–220 lm. The kinetics of drug release could be adjusted by varying the GS loading of the fibers and the suspension preparation conditions. Gradual release of *80% of the initial GS content was measured in phosphate buffered saline at 378C over 50 days from fibers spun from nonhomogenized suspensions, whereas loss of this amount of antibiotic occurred in less than 10 days from fibers spun from homogenized suspensions. Studies of growth inhibition of Stapyhlococcus epidermidis in culture indicated that GS released after 2 weeks from PCL fibers retained antibacterial activity. This behavior recommends further investigation of PCL fibers for local delivery of antibiotics to combat infection associated with periodontal disease, musculoskeletal injuries, and implantation of fiber-based tissue substitutes such as vascular prostheses.

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ID Code: 18529
Item Type: Journal Article
Refereed: Yes
Keywords: polycaprolactone, fibre, antibiotic, gentamicin sulphate
DOI: 10.1002/jbm.a.31476
ISSN: 1549-3296
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2008 Wiley InterScience
Copyright Statement: The definite version is available on publication at
Deposited On: 08 Mar 2009 23:38
Last Modified: 29 Feb 2012 13:47

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