Comparison of clinical body composition methods in people taking weight-inducing atypical antipsychotic medications

Sharpe, Jenny-Kay, Byrne, Nuala M., Stedman, Terry J., & Hills, Andrew P. (2008) Comparison of clinical body composition methods in people taking weight-inducing atypical antipsychotic medications. Asia Pacific Journal of Clinical Nutrition, 17(4), pp. 573-580.

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The purpose of this study was to compare the accuracy of clinical methods to estimate body fat (%BF) in people who take weight-inducing atypical antipsychotic medications. Forty-seven people (35 males, 12 females) with previously diagnosed psychotic illness who had been taking atypical antipsychotic medications for more than 6 months took part in this study. Percentage body fat was estimated using bioelectrical impedance analysis (BIA) and anthropometry from previously published prediction equations and compared with that measured using the deuterium dilution technique which served as the criterion measure. Bland-Altman analyses were used to assess the agreement between measures. In the males, %BF determined using BIA with the Lukaski equation was the only clinical method with mean differences that were not significant from criterion values. While in the females, %BF determined from BMI was the only method that was significantly different from the criterion values. All of the methods of estimating %BF except Watson equations provided consistent estimates across the weight range. Therefore, this study suggests that in a group of people who predominantly had schizophrenia and were taking atypical antipsychotic medications, BIA using the equation of Lukaski was the best indicator of %BF, although on an individual basis the accuracy was poor. BMI underestimated %BF to a greater significant extent than BIA. The use of BIA rather than BMI may provide a better indicator of adiposity in people who take weight inducing antipsychotic medications.

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1 citations in Scopus
2 citations in Web of Science®
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ID Code: 18815
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Bioelectric impedance, Obesity, Deuterium dilution, Percentage body fat, Atypical antipsychotic medication
ISSN: 0964-7058
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OTHER MEDICAL AND HEALTH SCIENCES (119900) > Medical and Health Sciences not elsewhere classified (119999)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 23 Apr 2009 02:22
Last Modified: 29 Feb 2012 13:50

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