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Magnetic resonance imaging and spectroscopy for monitoring liver steatosis

Cowin, Gary J. , Jonsson, Julie R. , Bauer, Judith D., Ash, Susan, Ali, Azmat , Osland, Emma J. , Purdie, David M. , Clouston, Andrew D. , Powell, Elizabeth E. , & Galloway, Graham J. (2008) Magnetic resonance imaging and spectroscopy for monitoring liver steatosis. Journal of Magnetic Resonance Imaging, 28(4), pp. 937-945.

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    Abstract

    Purpose: To compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content.

    Materials and Methods: Quantification of liver fat was compared by liver biopsy, proton MRS, and MRI using in-phase/out-of-phase (IP/OP) and plus/minus fat saturation (±FS) techniques. The reproducibility of each MR measure was also determined. An additional group of overweight patients with steatosis underwent hepatic MRI and MRS before and after a six-month weight-loss program.

    Results: A close correlation was demonstrated between histological assessment of steatosis and measurement of intrahepatocellular lipid (IHCL) by MRS (rs = 0.928, P < 0.0001) and MRI (IP/OP rs = 0.942, P < 0.0001; FS rs = 0.935, P < 0.0001). Following weight reduction, four of five patients with >5% weight loss had a decrease in IHCL of 50%.

    Conclusion: These findings suggest that standard MRI protocols provide a rapid, safe, and quantitative assessment of hepatic steatosis. This is important because MRS is not available on all clinical MRI systems. This will enable noninvasive monitoring of the effects of interventions such as weight loss or pharmacotherapy in patients with fatty liver diseases.

    Impact and interest:

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    58 citations in Web of Science®

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    ID Code: 18816
    Item Type: Journal Article
    Additional URLs:
    Keywords: Liver Fat, Obesity, Weight Loss, Insulin Resistance, Fatty Liver Disease
    DOI: 10.1002/jmri.21542
    ISSN: 10531807
    Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
    Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300)
    Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Gastroenterology and Hepatology (110307)
    Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Radiology and Organ Imaging (110320)
    Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > COGNITIVE SCIENCE (170200)
    Divisions: Current > QUT Faculties and Divisions > Faculty of Health
    Current > Institutes > Institute of Health and Biomedical Innovation
    Current > Schools > School of Public Health & Social Work
    Copyright Owner: Copyright 2008 Wiley Periodicals Inc
    Copyright Statement: The definitive version is available at www3.interscience.wiley.com
    Deposited On: 06 May 2009 07:41
    Last Modified: 05 Mar 2012 15:08

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