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Diurnal variation of axial length, intraocular pressure, and anterior eye biometrics

Read, Scott A., Collins, Michael, & Iskander, Daoud Robert (2008) Diurnal variation of axial length, intraocular pressure, and anterior eye biometrics. Investigative Ophthalmology & Visual Science, 49(7), pp. 2911-2918.

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Abstract

Purpose: To investigate the diurnal variation in axial length and anterior eye biometrics, whilst simultaneously measuring intraocular pressure (IOP) with dynamic contour tonometry in human subjects.--- Methods: Fifteen young adult near emmetropic subjects had their axial length, anterior eye biometrics (central corneal thickness and anterior chamber dimensions), and IOP measured at 6 different times across a 24 hour measurement period. Repeated measures ANOVA and sine curve fitting was used to analyze the diurnal rhythms in each measured parameter.--- Results: Axial length was found to undergo significant diurnal variation (p = 0.0006). The mean amplitude of axial length change was 0.046 ± 0.022 mm. The mean peak in axial length was found to occur at 11:13 am. Intraocular pressure and ocular pulse amplitude were also found to undergo significant diurnal change (p <0.0001 and 0.0006 respectively). The variation in axial length exhibited a significant association with the change in IOP (r = 0.37, p = 0.001). No significant difference was found between the mean peak times of axial length and intraocular pressure. Anterior eye biometric measures of central corneal thickness and anterior chamber depth were also found to undergo significant diurnal changes (p < 0.0001 and 0.0368 respectively).--- Conclusion: Axial length undergoes significant variation over a 24 hour period. Associations exist between the change in axial length and the change in IOP as measured by dynamic contour tonometry. These results may have significant implications for the role of ocular diurnal rhythms in emmetropization.

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ID Code: 19049
Item Type: Journal Article
Additional Information: A more recent version of this article appeared on July 1, 2008 Originally published In Press as doi:10.1167/iovs.08-1833 on March 24, 2008 06/10/2011 uploaded accepted version - please review and ad coversheet. Thanks. RS (Investigative Ophthalmology and Visual Science. 2008;49:2911-2918.) © 2008 by The Association for Research in Vision and Ophthalmology, Inc. DOI: 10.1167/iovs.08-1833 From the Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of Technology (QUT), Brisbane, Queensland, Australia. Supported by a QUT Institute of Biomedical Innovation 2007 Seeding Grant. Submitted for publication February 5, 2008; revised March 3, 2008; accepted 2008. Disclosure: S.A. Read, None; M.J. Collins, None; D.R. Iskander, None The publication costs of this article were defrayed in part by page charge payment. This article must therefore be marked “advertisement” in accordance with 18 U.S.C. §1734 solely to indicate this fact. Corresponding author: Scott A. Read, Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of Technology, Room B556, O Block, Victoria Park Road, Kelvin Grove 4059, Brisbane, Queensland, Australia; sa.read@qut.edu.au.
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Keywords: Medical Sciences - Ophthalmology and Optometry, Axial length, Intraocular pressure, Anterior eye biometrics
DOI: 10.1167/iovs.08-1833
ISSN: 0146-0404
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Optometry and Ophthalmology not elsewhere classified (111399)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Optometry & Vision Science
Copyright Owner: Copyright 2008 Association for Research in Vision and Ophthalmology
Deposited On: 17 Apr 2009 12:59
Last Modified: 01 Mar 2012 09:52

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