In vivo study of changes in refractive index distribution in the human crystalline lens with age and accommodation

Kasthurirangan, Sanjeev, Markwell, Emma L., Atchison, David A., & Pope, James M. (2008) In vivo study of changes in refractive index distribution in the human crystalline lens with age and accommodation. Investigative Ophthalmology & Visual Science, 49(6), pp. 2531-2540.

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PURPOSE: Magnetic resonance imaging (MRI) was used to map the refractive index distribution in human eye lenses in vivo and to investigate changes with age and accommodation.----

METHODS: Whole-eye MR images were obtained for sagittal and transverse axial planes in one eye each of 15 young (19–29 years) and 15 older (60–70 years) subjects when viewing a far (6 m) target and at individual near points in the young subjects. Refractive index maps of the crystalline lens were calculated by using a procedure previously validated in vitro.----

RESULTS: A central high refractive index plateau region and sharp decline in refractive index at the periphery were seen in all three groups. The peripheral decline was steepest in the older lenses and least steep in the young accommodated lenses. Average lens thickness increased (+0.27 mm; P < 0.05) and equatorial diameter decreased (–0.35 mm; P < 0.05) with accommodation. Axial thickness (+0.96 mm; P < 0.05) and equatorial diameter (+0.28 mm; P < 0.05) increased with age. The central index (1.409 ± 0.008) did not differ between groups. The axial thickness of the central plateau increased with age (+0.83 mm; P < 0.05) but not significantly with accommodation. The equatorial diameter of the central plateau increased with age (+0.56 mm; P < 0.01) and decreased with accommodation (–0.43 mm; P < 0.05).----

CONCLUSIONS. The refractive index of the central plateau region does not change significantly with accommodation or ageing, but its size increases with age and the peripheral decline in refractive index becomes steeper in older lenses.

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ID Code: 20183
Item Type: Journal Article
Refereed: Yes
Additional Information: This is not the final published version
Additional URLs:
Keywords: Crystalline Lens, Refractive Index, Accommodation, MRI, Age-related Changes
DOI: 10.1167/iovs.07-1443
ISSN: 0146-0404
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Copyright Owner: Copyright 2008 Association for Research in Vision and Ophthalmology
Deposited On: 28 Apr 2009 05:21
Last Modified: 09 Apr 2014 12:21

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