The incidence of contact lens-related microbial keratitis in Australia

Stapleton, Fiona, Keay, Lisa, Edwards, Katie P., Naduvilath, Thomas, Dart, John, Brian, Garry, & Holden, Brien A. (2008) The incidence of contact lens-related microbial keratitis in Australia. Ophthalmology, 115(10), pp. 1655-1662.

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OBJECTIVE: To establish the absolute risk of contact lens (CL)-related microbial keratitis, the incidence of vision loss and risk factors for disease. DESIGN: A prospective, 12-month, population-based surveillance study. PARTICIPANTS: New cases of CL-related microbial keratitis presenting in Australia over a 12-month period were identified through surveillance of all ophthalmic practitioners (numerator). Case detection was augmented by records' audits at major ophthalmic centers. The denominator (number of wearers of different CL types in the community) was established using a national telephone survey of 35,914 individuals. TESTING: Cases and controls were interviewed by telephone to determine subject demographics and CL wear history. Visual outcomes were determined 6 months after the initial event. Annualized incidence and confidence intervals (CI) were estimated for different severities of disease and multivariable analysis was used in risk factor analysis. MAIN OUTCOME MEASURES: Annualized incidence (with CI) of disease and vision loss by CL type and wear modality and identification of independent risk factors. RESULTS: We identified 285 eligible cases of CL-related microbial keratitis and 1798 controls. In daily wear rigid gas-permeable CL wearers, the annualized incidence per 10,000 wearers was 1.2 (CI, 1.1-1.5); in daily wear soft CL wearers 1.9 (CI, 1.8-2.0); soft CL wearers (occasional overnight use) 2.2 (CI, 2.0-2.5); daily disposable CL wearers 2.0 (CI, 1.7-2.4); daily disposable CL wearers (occasional overnight use) 4.2 (CI, 3.1-6.6); daily wear silicone hydrogel CL wearers 11.9 (CI, 10.0-14.6); silicone hydrogel CL wearers (occasional overnight use) 5.5 (CI, 4.5-7.2); overnight wear soft CL wearers 19.5 (CI, 14.6-29.5) and in overnight wear of silicone hydrogel 25.4 (CI, 21.2-31.5). Loss of vision occurred in 0.6 per 10,000 wearers. Risk factors included overnight use, poor storage case hygiene, smoking, Internet purchase of CLs, <6 months wear experience, and higher socioeconomic class. CONCLUSIONS: Incidence estimates for soft CL use were similar to those previously reported. New lens types have not reduced the incidence of disease. Overnight use of any CL is associated with a higher risk than daily use.

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ID Code: 20552
Item Type: Journal Article
Refereed: Yes
Additional Information: Accession Number: 18538404 Language: English. Date Created: 20081020. Date Completed: 20081030. Update Code: 20081217. Publication Type: Journal Article; Research Support, Non-U.S. Gov't. Journal ID: 7802443. Publication Model: Print-Electronic. Cited Medium: Internet. NLM ISO Abbr: Ophthalmology
Keywords: Contact Lenses/*adverse effects, Corneal Ulcer/*epidemiology, Eye Infections, Bacterial/*epidemiology, Adolescent, Adult, Australia/epidemiology, Bacteria/isolation & purification, Contact Lenses/utilization, Corneal Ulcer/microbiology, Eye Infections, Bacterial/microbiology, Female, Health Surveys, Humans, Incidence, Male, Middle Aged, Population Surveillance, Prospective Studies, Risk Factors
DOI: 10.1016/j.ophtha.2008.04.002
ISSN: 1549-4713
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 20 May 2009 23:22
Last Modified: 10 Aug 2011 17:36

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