The association between MC1R genotype and BRAF mutation status in cutaneous melanoma: Findings from an Australian population

Hacker, Elke, Hayward, Nicholas K., Dumenil, Troy, James, Michael R., & Whiteman, David C. (2009) The association between MC1R genotype and BRAF mutation status in cutaneous melanoma: Findings from an Australian population. In 7th World Congress on Melanoma / 5th Congress of the European Association of Dermato-Oncology, 12-16 May 2009, Vienna, Austria.

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There is increasing epidemiologic and molecular evidence that cutaneous melanomas arise through multiple causal pathways. The purpose of this study was to explore the relationship between germline and somatic mutations in a population-based series of melanoma patients to reshape and refine the divergent pathway model for melanoma. Melanomas collected from 123 Australian patients were analyzed for MC1R variants and mutations in the BRAF and NRAS genes. Detailed phenotypic and sun exposure data were systematically collected from all patients. We found that BRAF-mutant melanomas were significantly more likely from younger patients and those with high nevus counts, and were more likely in melanomas with adjacent neval remnants. Conversely, BRAF¬-mutant melanomas were significantly less likely in people with high levels of life-time sun exposure. We observed no association between germline MC1R status and somatic BRAF mutations in melanomas from this population. BRAF-mutant melanomas have different origins from other cutaneous melanomas. These data support the divergent pathways hypothesis for melanoma, which may require a reappraisal of targeted cancer prevention activities.

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ID Code: 21079
Item Type: Conference Paper
Refereed: Yes
Additional URLs:
Keywords: Melanoma, MC1R variants, BRAF-mutant melanomas, Germlines, Somatic mutations
DOI: 10.1038/jid.2009.182
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Public Health and Health Services not elsewhere classified (111799)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2009 The Author(s)
Deposited On: 11 Jun 2009 01:30
Last Modified: 22 Jun 2017 14:41

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